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Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants.
Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, Boyd LF, Nguyen H, Pomerenke A, Stephens T, Olia AS, Zhang B, De Giorgi V, Holbrook MR, Gross R, Postnikova E, Garza NL, Johnson RF, Margulies DH, Kwong PD, Alter HJ, Buchholz UJ, Lusso P, Farci P. Chen Z, et al. Among authors: kwong pd. Cell Rep. 2022 Nov 1;41(5):111528. doi: 10.1016/j.celrep.2022.111528. Epub 2022 Sep 30. Cell Rep. 2022. PMID: 36302375 Free PMC article.
Extremely potent monoclonal antibodies neutralize Omicron and other SARS-CoV-2 variants.
Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, Boyd LF, Nguyen H, Pomerenke A, Stephens T, Olia AS, De Giorgi V, Holbrook MR, Gross R, Postnikova E, Garza NL, Johnson RF, Margulies DH, Kwong PD, Alter HJ, Buchholz UJ, Lusso P, Farci P. Chen Z, et al. Among authors: kwong pd. medRxiv [Preprint]. 2022 Jan 13:2022.01.12.22269023. doi: 10.1101/2022.01.12.22269023. medRxiv. 2022. Update in: Cell Rep. 2022 Nov 1;41(5):111528. doi: 10.1016/j.celrep.2022.111528 PMID: 35043120 Free PMC article. Updated. Preprint.
Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins.
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Boyd H, Tsybovsky Y, Krammer F, Diamond MS, Kwong PD, An Z, Chen Z. Chonira V, et al. Among authors: kwong pd. bioRxiv [Preprint]. 2022 May 31:2022.05.30.493765. doi: 10.1101/2022.05.30.493765. bioRxiv. 2022. Update in: Nat Chem Biol. 2023 Mar;19(3):284-291. doi: 10.1038/s41589-022-01193-2 PMID: 35677079 Free PMC article. Updated. Preprint.
A multispecific antibody prevents immune escape and confers pan-SARS-CoV-2 neutralization.
Misasi J, Wei RR, Wang L, Pegu A, Wei CJ, Oloniniyi OK, Zhou T, Moliva JI, Zhao B, Choe M, Yang ES, Zhang Y, Boruszczak M, Chen M, Leung K, Li J, Yang ZY, Andersen H, Carlton K, Godbole S, Harris DR, Henry AR, Ivleva VB, Lei P, Liu C, Longobardi L, Merriam JS, Nase D, Olia AS, Pessaint L, Porto M, Shi W, Wolff JJ, Douek DC, Suthar MS, Gall J, Koup RA, Kwong PD, Mascola JR, Nabel GJ, Sullivan NJ. Misasi J, et al. Among authors: kwong pd. bioRxiv [Preprint]. 2022 Nov 21:2022.07.29.502029. doi: 10.1101/2022.07.29.502029. bioRxiv. 2022. Update in: Sci Transl Med. 2024 Oct 9;16(768):eado9026. doi: 10.1126/scitranslmed.ado9026 PMID: 35982683 Free PMC article. Updated. Preprint.
Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design.
Holt GT, Gorman J, Wang S, Lowegard AU, Zhang B, Liu T, Lin BC, Louder MK, Frenkel MS, McKee K, O'Dell S, Rawi R, Shen CH, Doria-Rose NA, Kwong PD, Donald BR. Holt GT, et al. Among authors: kwong pd. Cell Rep. 2023 Jul 25;42(7):112711. doi: 10.1016/j.celrep.2023.112711. Epub 2023 Jul 11. Cell Rep. 2023. PMID: 37436900 Free PMC article.
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques.
Buchholz U, Kaiser J, Nelson C, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Ahlers L, Herbert R, Moore I, Wilder-Kofie T, Moore R, Walker A, Lijuan Y, Munir S, Teng IT, Kwong P, Dowdell K, Nguyen H, Kim J, Cohen J, Johnson RF, Garza N, Via L, Barber D, LE Nouen C. Buchholz U, et al. Res Sq [Preprint]. 2023 Sep 13:rs.3.rs-3278289. doi: 10.21203/rs.3.rs-3278289/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Apr 26;15(1):3553. doi: 10.1038/s41467-024-47784-6 PMID: 37790295 Free PMC article. Updated. Preprint.
Intranasal parainfluenza virus-vectored vaccine expressing SARS-CoV-2 spike protein of Delta or Omicron B.1.1.529 induces mucosal and systemic immunity and protects hamsters against homologous and heterologous challenge.
Park HS, Matsuoka Y, Santos C, Luongo C, Liu X, Yang L, Kaiser JA, Duncan EF, Johnson RF, Teng IT, Kwong PD, Buchholz UJ, Le Nouën C. Park HS, et al. Among authors: kwong pd. bioRxiv [Preprint]. 2024 Sep 13:2024.09.12.612598. doi: 10.1101/2024.09.12.612598. bioRxiv. 2024. PMID: 39372768 Free PMC article. Preprint.
A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses.
Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD. Wang P, et al. Among authors: kwong pd. bioRxiv [Preprint]. 2021 Oct 14:2021.10.13.464307. doi: 10.1101/2021.10.13.464307. bioRxiv. 2021. Update in: Emerg Microbes Infect. 2022 Dec;11(1):147-157. doi: 10.1080/22221751.2021.2011623 PMID: 34671769 Free PMC article. Updated. Preprint.
Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.
Lima NS, Musayev M, Johnston TS, Wagner DA, Henry AR, Wang L, Yang ES, Zhang Y, Birungi K, Black WP, O'Dell S, Schmidt SD, Moon D, Lorang CG, Zhao B, Chen M, Boswell KL, Roberts-Torres J, Davis RL, Peyton L, Narpala SR, O'Connell S, Wang J, Schrager A, Talana CA, Leung K, Shi W, Khashab R, Biber A, Zilberman T, Rhein J, Vetter S, Ahmed A, Novik L, Widge A, Gordon I, Guech M, Teng IT, Phung E, Ruckwardt TJ, Pegu A, Misasi J, Doria-Rose NA, Gaudinski M, Koup RA, Kwong PD, McDermott AB, Amit S, Schacker TW, Levy I, Mascola JR, Sullivan NJ, Schramm CA, Douek DC. Lima NS, et al. Among authors: kwong pd. bioRxiv [Preprint]. 2022 Jun 30:2022.03.28.486152. doi: 10.1101/2022.03.28.486152. bioRxiv. 2022. Update in: Nat Commun. 2022 Dec 14;13(1):7733. doi: 10.1038/s41467-022-35456-2 PMID: 35378757 Free PMC article. Updated. Preprint.
467 results