Tian X - Search Results

1

Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.

Tian X, Suarez D, Thomson D, Li W, King EA, LaFrance L, Boehm J, Barton L, Di Marco C, Martyr C, Thalji R, Medina J, Knight S, Heerding D, Gao E, Nartey E, Cecconie T, Nixon C, Zhang G, Berrodin TJ, Phelps C, Patel A, Bai X, Lind K, Prabhu N, Messer J, Zhu Z, Shewchuk L, Reid R, Graves AP, McHugh C, Mangatt B. Tian X, et al. J Med Chem. 2022 Nov 10;65(21):14391-14408. doi: 10.1021/acs.jmedchem.2c00670. Epub 2022 Oct 27. J Med Chem. 2022. PMID: 36302181

2

Design and synthesis of aminopyridine containing biaryls reducing c-MYC protein levels in cells.

Di Marco CN, Terrell L, Sanchez R, Rueda L, Shuster L, Nartey EN, McHugh C, Mack JF, Shu A, Tian X, Medina JR, Rivero R, Manetsch R, Heerding D, Mangatt B. Di Marco CN, et al. Among authors: tian x. Bioorg Med Chem Lett. 2023 Aug 15;92:129385. doi: 10.1016/j.bmcl.2023.129385. Epub 2023 Jun 18. Bioorg Med Chem Lett. 2023. PMID: 37339719

3

Design, synthesis, and evaluation of proline based melanocortin receptor ligands.

Tian X, Field T, Mazur AW, Ebetino FH, Wos JA, Crossdoersen D, Pinney BB, Sheldon RJ. Tian X, et al. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2819-23. doi: 10.1016/j.bmcl.2005.03.120. Bioorg Med Chem Lett. 2005. PMID: 15911261

4

Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach.

Tian X, Field TB, Switzer AG, Mazur AW, Ebetino FH, Wos JA, Berberich SM, Jayasinghe LR, Obringer CM, Dowty ME, Pinney BB, Farmer JA, Crossdoersen D, Sheldon RJ. Tian X, et al. J Med Chem. 2006 Jul 27;49(15):4745-61. doi: 10.1021/jm060384p. J Med Chem. 2006. PMID: 16854081

5

Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.

Tian X, Switzer AG, Derose SA, Mishra RK, Solinsky MG, Mumin RN, Ebetino FH, Jayasinghe LR, Webster ME, Colson AO, Crossdoersen D, Pinney BB, Farmer JA, Dowty ME, Obringer CM, Cruze CA, Burklow ML, Suchanek PM, Dong L, Dirr MK, Sheldon RJ, Wos JA. Tian X, et al. J Med Chem. 2008 Oct 9;51(19):6055-66. doi: 10.1021/jm800525p. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771254

6

CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists.

Hsin LW, Tian X, Webster EL, Coop A, Caldwell TM, Jacobson AE, Chrousos GP, Gold PW, Habib KE, Ayala A, Eckelman WC, Contoreggi C, Rice KC. Hsin LW, et al. Among authors: tian x. Bioorg Med Chem. 2002 Jan;10(1):175-83. doi: 10.1016/s0968-0896(01)00261-9. Bioorg Med Chem. 2002. PMID: 11738619

7

Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists.

Tian X, Chen X, Gan L, Hayes JC, Switzer AG, Solinsky MG, Ebetino FH, Wos JA, Pinney BB, Farmer JA, Crossdoersen D, Sheldon RJ. Tian X, et al. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. doi: 10.1016/j.bmcl.2005.12.005. Epub 2005 Dec 20. Bioorg Med Chem Lett. 2006. PMID: 16376076

8

Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.

Yu H, Kim IJ, Folk JE, Tian X, Rothman RB, Baumann MH, Dersch CM, Flippen-Anderson JL, Parrish D, Jacobson AE, Rice KC. Yu H, et al. Among authors: tian x. J Med Chem. 2004 May 6;47(10):2624-34. doi: 10.1021/jm0305873. J Med Chem. 2004. PMID: 15115403

9

Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists.

Tian X, Mishra RK, Switzer AG, Hu XE, Kim N, Mazur AW, Ebetino FH, Wos JA, Crossdoersen D, Pinney BB, Farmer JA, Sheldon RJ. Tian X, et al. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4668-73. doi: 10.1016/j.bmcl.2006.05.087. Bioorg Med Chem Lett. 2006. PMID: 16766182

10

The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type.

Tian X, Hsin LW, Webster EL, Contoreggi C, Chrousos GP, Gold PW, Habib K, Ayala A, Eckelman WC, Jacobson AE, Rice KC. Tian X, et al. Bioorg Med Chem Lett. 2001 Feb 12;11(3):331-3. doi: 10.1016/s0960-894x(00)00661-2. Bioorg Med Chem Lett. 2001. PMID: 11212103

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