Suzuki Y - Search Results

1

Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein.

Park JS, Choi J, Cao L, Mohanty J, Suzuki Y, Park A, Baker D, Schlessinger J, Lee S. Park JS, et al. Among authors: suzuki y. Cell Rep. 2022 Oct 25;41(4):111545. doi: 10.1016/j.celrep.2022.111545. Cell Rep. 2022. PMID: 36288716 Free PMC article.

2

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.

Reshetnyak AV, Nelson B, Shi X, Boggon TJ, Pavlenco A, Mandel-Bausch EM, Tome F, Suzuki Y, Sidhu SS, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: suzuki y. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17832-7. doi: 10.1073/pnas.1317118110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127596 Free PMC article.

3

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.

Liosi ME, Krimmer SG, Newton AS, Dawson TK, Puleo DE, Cutrona KJ, Suzuki Y, Schlessinger J, Jorgensen WL. Liosi ME, et al. Among authors: suzuki y. J Med Chem. 2020 May 28;63(10):5324-5340. doi: 10.1021/acs.jmedchem.0c00192. Epub 2020 May 8. J Med Chem. 2020. PMID: 32329617 Free PMC article.

4

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.

Suzuki Y, Kuzina E, An SJ, Tome F, Mohanty J, Li W, Lee S, Liu Y, Lax I, Schlessinger J. Suzuki Y, et al. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31800-31807. doi: 10.1073/pnas.2018554117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257569 Free PMC article.

5

Structural basis for ligand reception by anaplastic lymphoma kinase.

Li T, Stayrook SE, Tsutsui Y, Zhang J, Wang Y, Li H, Proffitt A, Krimmer SG, Ahmed M, Belliveau O, Walker IX, Mudumbi KC, Suzuki Y, Lax I, Alvarado D, Lemmon MA, Schlessinger J, Klein DE. Li T, et al. Among authors: suzuki y. Nature. 2021 Dec;600(7887):148-152. doi: 10.1038/s41586-021-04141-7. Epub 2021 Nov 24. Nature. 2021. PMID: 34819665 Free PMC article.

6

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability.

An SJ, Mohanty J, Tome F, Suzuki Y, Lax I, Schlessinger J. An SJ, et al. Among authors: suzuki y. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2219128120. doi: 10.1073/pnas.2219128120. Epub 2023 Feb 6. Proc Natl Acad Sci U S A. 2023. PMID: 36745784 Free PMC article.

7

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.

Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J. Krimmer SG, et al. Among authors: suzuki y. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2300054120. doi: 10.1073/pnas.2300054120. Epub 2023 Mar 21. Proc Natl Acad Sci U S A. 2023. PMID: 36943885 Free PMC article.

8

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.

Zhang KY, Card GL, Suzuki Y, Artis DR, Fong D, Gillette S, Hsieh D, Neiman J, West BL, Zhang C, Milburn MV, Kim SH, Schlessinger J, Bollag G. Zhang KY, et al. Among authors: suzuki y. Mol Cell. 2004 Jul 23;15(2):279-86. doi: 10.1016/j.molcel.2004.07.005. Mol Cell. 2004. PMID: 15260978 Free article.

9

Structural basis for the activity of drugs that inhibit phosphodiesterases.

Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY. Card GL, et al. Among authors: suzuki y. Structure. 2004 Dec;12(12):2233-47. doi: 10.1016/j.str.2004.10.004. Structure. 2004. PMID: 15576036 Free article.

10

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.

Card GL, Blasdel L, England BP, Zhang C, Suzuki Y, Gillette S, Fong D, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY. Card GL, et al. Among authors: suzuki y. Nat Biotechnol. 2005 Feb;23(2):201-7. doi: 10.1038/nbt1059. Epub 2005 Jan 30. Nat Biotechnol. 2005. PMID: 15685167 Free article.

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