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Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes.
MacDonald DA, Martin J, Muthusamy KK, Luo JK, Pyles E, Rafique A, Huang T, Potocky T, Liu Y, Cao J, Bono F, Delesque N, Savi P, Francis J, Amirkhosravi A, Meyer T, Romano C, Glinka M, Yancopoulos GD, Stahl N, Wiegand SJ, Papadopoulos N. MacDonald DA, et al. Among authors: romano c. Angiogenesis. 2016 Jul;19(3):389-406. doi: 10.1007/s10456-016-9515-8. Epub 2016 May 27. Angiogenesis. 2016. PMID: 27234973 Free PMC article.
Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.
Latuszek A, Liu Y, Olsen O, Foster R, Cao M, Lovric I, Yuan M, Liu N, Chen H, Zhang Q, Xiao H, Springer C, Ehrlich G, Kamat V, Rafique A, Hu Y, Krueger P, Huang T, Poueymirou W, Babb R, Rosconi MP, Retter MW, Chen G, Morton L, Zambrowicz B, Cao J, Romano C, Olson WC. Latuszek A, et al. Among authors: romano c. PLoS One. 2020 May 8;15(5):e0231892. doi: 10.1371/journal.pone.0231892. eCollection 2020. PLoS One. 2020. PMID: 32384086 Free PMC article.
The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells.
Deckelbaum RA, Lobov IB, Cheung E, Halasz G, Rajamani S, Lerner J, Tong C, Li Z, Boland P, Dominguez M, Hughes V, Yancopoulos GD, Murphy AJ, Thurston G, Cao J, Romano C, Gale NW. Deckelbaum RA, et al. Among authors: romano c. Angiogenesis. 2020 May;23(2):179-192. doi: 10.1007/s10456-019-09696-8. Epub 2019 Nov 21. Angiogenesis. 2020. PMID: 31754927 Free PMC article.
Production of large, defined genome modifications in rats by targeting rat embryonic stem cells.
Lee J, Wang J, Ally R, Trzaska S, Hickey J, Mujica A, Miloscio L, Mastaitis J, Morse B, Smith J, Atanasio A, Chiao E, Chen H, Latuszek A, Hu Y, Valenzuela D, Romano C, Zambrowicz B, Auerbach W. Lee J, et al. Among authors: romano c. Stem Cell Reports. 2023 Jan 10;18(1):394-409. doi: 10.1016/j.stemcr.2022.11.012. Epub 2022 Dec 15. Stem Cell Reports. 2023. PMID: 36525967 Free PMC article.
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid.
Lehmann GL, Hanke-Gogokhia C, Hu Y, Bareja R, Salfati Z, Ginsberg M, Nolan DJ, Mendez-Huergo SP, Dalotto-Moreno T, Wojcinski A, Ochoa F, Zeng S, Cerliani JP, Panagis L, Zager PJ, Mullins RF, Ogura S, Lutty GA, Bang J, Zippin JH, Romano C, Rabinovich GA, Elemento O, Joyner AL, Rafii S, Rodriguez-Boulan E, Benedicto I. Lehmann GL, et al. Among authors: romano c. J Exp Med. 2020 Jun 1;217(6):e20190730. doi: 10.1084/jem.20190730. J Exp Med. 2020. PMID: 32196081 Free PMC article.
Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics.
Patel G, Fury W, Yang H, Gomez-Caraballo M, Bai Y, Yang T, Adler C, Wei Y, Ni M, Schmitt H, Hu Y, Yancopoulos G, Stamer WD, Romano C. Patel G, et al. Among authors: romano c. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12856-12867. doi: 10.1073/pnas.2001896117. Epub 2020 May 21. Proc Natl Acad Sci U S A. 2020. PMID: 32439707 Free PMC article.
1,854 results