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A Biparatopic Antibody That Modulates MET Trafficking Exhibits Enhanced Efficacy Compared with Parental Antibodies in MET-Driven Tumor Models.
DaSilva JO, Yang K, Perez Bay AE, Andreev J, Ngoi P, Pyles E, Franklin MC, Dudgeon D, Rafique A, Dore A, Delfino FJ, Potocky TB, Babb R, Chen G, MacDonald D, Olson WC, Thurston G, Daly C. DaSilva JO, et al. Clin Cancer Res. 2020 Mar 15;26(6):1408-1419. doi: 10.1158/1078-0432.CCR-19-2428. Epub 2019 Dec 17. Clin Cancer Res. 2020. PMID: 31848185
A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade.
DaSilva JO, Yang K, Surriga O, Nittoli T, Kunz A, Franklin MC, Delfino FJ, Mao S, Zhao F, Giurleo JT, Kelly MP, Makonnen S, Hickey C, Krueger P, Foster R, Chen Z, Retter MW, Slim R, Young TM, Olson WC, Thurston G, Daly C. DaSilva JO, et al. Mol Cancer Ther. 2021 Oct;20(10):1966-1976. doi: 10.1158/1535-7163.MCT-21-0009. Epub 2021 Jul 26. Mol Cancer Ther. 2021. PMID: 34315762 Free PMC article.
Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020.
Munyua P, Osoro E, Jones J, Njogu G, Yang G, Hunsperger E, Szablewski CM, Njoroge R, Marwanga D, Oyas H, Andagalu B, Ndanyi R, Otieno N, Obanda V, Nasimiyu C, Njagi O, DaSilva J, Jang Y, Barnes J, Emukule GO, Onyango CO, Davis CT. Munyua P, et al. Among authors: dasilva j. Viruses. 2024 Sep 5;16(9):1417. doi: 10.3390/v16091417. Viruses. 2024. PMID: 39339892 Free PMC article.
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation.
Friedrichs GS, Abernathy MM, Ackley D, Clark M, DaSilva JK, Foley CM, Greiter-Wilke A, Henderson KA, Kremer JJ, Morimoto BH, Paglialunga S, Pugsley MK, Regan CP, Rossman EI, Segretti JA, Traebert M, Vargas HM, Wisialowski TA. Friedrichs GS, et al. Among authors: dasilva jk. Regul Toxicol Pharmacol. 2024 Nov;153:105706. doi: 10.1016/j.yrtph.2024.105706. Epub 2024 Sep 16. Regul Toxicol Pharmacol. 2024. PMID: 39293707
270 results