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Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons.
Pak C, Danko T, Mirabella VR, Wang J, Liu Y, Vangipuram M, Grieder S, Zhang X, Ward T, Huang YA, Jin K, Dexheimer P, Bardes E, Mitelpunkt A, Ma J, McLachlan M, Moore JC, Qu P, Purmann C, Dage JL, Swanson BJ, Urban AE, Aronow BJ, Pang ZP, Levinson DF, Wernig M, Südhof TC. Pak C, et al. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2025598118. doi: 10.1073/pnas.2025598118. Proc Natl Acad Sci U S A. 2021. PMID: 34035170 Free PMC article.
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism.
Wang L, Mirabella VR, Dai R, Su X, Xu R, Jadali A, Bernabucci M, Singh I, Chen Y, Tian J, Jiang P, Kwan KY, Pak C, Liu C, Comoletti D, Hart RP, Chen C, Südhof TC, Pang ZP. Wang L, et al. Among authors: pak c. Mol Psychiatry. 2024 Jun;29(6):1620-1635. doi: 10.1038/s41380-022-01834-x. Epub 2022 Oct 24. Mol Psychiatry. 2024. PMID: 36280753 Free PMC article.
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.
Pak C, Garshasbi M, Kahrizi K, Gross C, Apponi LH, Noto JJ, Kelly SM, Leung SW, Tzschach A, Behjati F, Abedini SS, Mohseni M, Jensen LR, Hu H, Huang B, Stahley SN, Liu G, Williams KR, Burdick S, Feng Y, Sanyal S, Bassell GJ, Ropers HH, Najmabadi H, Corbett AH, Moberg KH, Kuss AW. Pak C, et al. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12390-5. doi: 10.1073/pnas.1107103108. Epub 2011 Jul 6. Proc Natl Acad Sci U S A. 2011. PMID: 21734151 Free PMC article.
Generation of induced neuronal cells by the single reprogramming factor ASCL1.
Chanda S, Ang CE, Davila J, Pak C, Mall M, Lee QY, Ahlenius H, Jung SW, Südhof TC, Wernig M. Chanda S, et al. Among authors: pak c. Stem Cell Reports. 2014 Aug 12;3(2):282-96. doi: 10.1016/j.stemcr.2014.05.020. Epub 2014 Jul 4. Stem Cell Reports. 2014. PMID: 25254342 Free PMC article.
691 results