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Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
Leonard EK, Tomala J, Gould JR, Leff MI, Lin JX, Li P, Porter MJ, Johansen ER, Thompson L, Cao SD, Hou S, Henclova T, Huliciak M, Sargunas PR, Fabilane CS, Vaněk O, Kovar M, Schneider B, Raimondi G, Leonard WJ, Spangler JB. Leonard EK, et al. Among authors: henclova t. JCI Insight. 2024 Sep 24;9(18):e173469. doi: 10.1172/jci.insight.173469. JCI Insight. 2024. PMID: 39115939 Free PMC article.
Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity.
Leonard EK, Tomala J, Gould JR, Leff MI, Lin JX, Li P, Porter MJ, Johansen ER, Thompson L, Cao SD, Henclova T, Huliciak M, Vaněk O, Kovar M, Leonard WJ, Spangler JB. Leonard EK, et al. Among authors: henclova t. bioRxiv [Preprint]. 2023 May 4:2023.05.03.539272. doi: 10.1101/2023.05.03.539272. bioRxiv. 2023. Update in: JCI Insight. 2024 Sep 24;9(18):e173469. doi: 10.1172/jci.insight.173469 PMID: 37205604 Free PMC article. Updated. Preprint.
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
VanDyke D, Iglesias M, Tomala J, Young A, Smith J, Perry JA, Gebara E, Cross AR, Cheung LS, Dykema AG, Orcutt-Jahns BT, Henclová T, Golias J, Balolong J, Tomasovic LM, Funda D, Meyer AS, Pardoll DM, Hester J, Issa F, Hunter CA, Anderson MS, Bluestone JA, Raimondi G, Spangler JB. VanDyke D, et al. Among authors: henclova t. Cell Rep. 2022 Oct 18;41(3):111478. doi: 10.1016/j.celrep.2022.111478. Cell Rep. 2022. PMID: 36261022 Free PMC article.