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Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
Nye TM, Tükenmez H, Singh P, Flores-Mireles AL, Obernuefemann CLP, Pinkner JS, Sarkar S, Bonde M, Lindgren AEG, Dodson KW, Johansson J, Almqvist F, Caparon MG, Hultgren SJ. Nye TM, et al. Among authors: hultgren sj. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2210912119. doi: 10.1073/pnas.2210912119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252016 Free PMC article.
Adhesin presentation in bacteria requires molecular chaperones and ushers.
Jones CH, Jacob-Dubuisson F, Dodson K, Kuehn M, Slonim L, Striker R, Hultgren SJ. Jones CH, et al. Among authors: hultgren sj. Infect Immun. 1992 Nov;60(11):4445-51. doi: 10.1128/iai.60.11.4445-4451.1992. Infect Immun. 1992. PMID: 1356928 Free PMC article. Review. No abstract available.
325 results