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A novel dual mode-of-action anti-hyperalgesic compound in rats which is neuroprotective and promotes neuroregeneration.
Bloms-Funke P, Schumacher M, Liu S, Su D, Li J, Liere P, Rupprecht R, Nothdurfter C, Bahrenberg G, Christoph T, Habermann C, Kneip C, Schröder W, Tzschentke TM, Saunders D. Bloms-Funke P, et al. Among authors: christoph t. Eur J Pharmacol. 2022 May 15;923:174935. doi: 10.1016/j.ejphar.2022.174935. Epub 2022 Apr 2. Eur J Pharmacol. 2022. PMID: 35378102
Voltage-gated calcium currents in human dorsal root ganglion neurons.
Hartung JE, Moy JK, Loeza-Alcocer E, Nagarajan V, Jostock R, Christoph T, Schroeder W, Gold MS. Hartung JE, et al. Among authors: christoph t. Pain. 2022 Jun 1;163(6):e774-e785. doi: 10.1097/j.pain.0000000000002465. Epub 2021 Aug 27. Pain. 2022. PMID: 34510139 Free PMC article.
2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists.
Kang JM, Kwon SO, Ann J, Lee S, Kim C, Do N, Jeong JJ, Blumberg PM, Ha H, Vu TNL, Yoon S, Choi S, Frank-Foltyn R, Lesch B, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Kang JM, et al. Among authors: christoph t. Bioorg Med Chem Lett. 2021 Sep 15;48:128266. doi: 10.1016/j.bmcl.2021.128266. Epub 2021 Jul 14. Bioorg Med Chem Lett. 2021. PMID: 34273488
RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener.
Valdor M, Wagner A, Fischer H, Röhrs V, Schröder W, Bahrenberg G, Welbers A, Fechner H, Kurreck J, Tzschentke TM, Christoph T. Valdor M, et al. Among authors: christoph t. J Pharmacol Toxicol Methods. 2020 May-Jun;103:106693. doi: 10.1016/j.vascn.2020.106693. Epub 2020 Apr 8. J Pharmacol Toxicol Methods. 2020. PMID: 32276047
Discovery of indane propanamides as potent and selective TRPV1 antagonists.
Ahn S, Kim YS, Kim MS, Ann J, Ha H, Yoo YD, Kim YH, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Ahn S, et al. Among authors: christoph t. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126838. doi: 10.1016/j.bmcl.2019.126838. Epub 2019 Dec 3. Bioorg Med Chem Lett. 2020. PMID: 31864799
82 results