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Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JN, Dos Santos Souza C, Zhang S, Castelli L, Hautbergue G, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J. Moll T, et al. Among authors: rehwinkel j. Life Sci Alliance. 2022 Oct 14;6(1):e202201449. doi: 10.26508/lsa.202201449. Print 2023 Jan. Life Sci Alliance. 2022. PMID: 36241425 Free PMC article.
A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.
Wing PA, Davenne T, Wettengel J, Lai AG, Zhuang X, Chakraborty A, D'Arienzo V, Kramer C, Ko C, Harris JM, Schreiner S, Higgs M, Roessler S, Parish JL, Protzer U, Balfe P, Rehwinkel J, McKeating JA. Wing PA, et al. Among authors: rehwinkel j. Life Sci Alliance. 2019 Mar 27;2(2):e201900355. doi: 10.26508/lsa.201900355. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30918010 Free PMC article.
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JNG, Souza CDS, Zhang S, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J. Moll T, et al. Among authors: rehwinkel j. bioRxiv [Preprint]. 2022 Mar 7:2022.03.06.483172. doi: 10.1101/2022.03.06.483172. bioRxiv. 2022. Update in: Life Sci Alliance. 2022 Oct 14;6(1):e202201449. doi: 10.26508/lsa.202201449 PMID: 35291294 Free PMC article. Updated. Preprint.
RNA degradation in antiviral immunity and autoimmunity.
Rigby RE, Rehwinkel J. Rigby RE, et al. Among authors: rehwinkel j. Trends Immunol. 2015 Mar;36(3):179-88. doi: 10.1016/j.it.2015.02.001. Epub 2015 Feb 20. Trends Immunol. 2015. PMID: 25709093 Free PMC article. Review.
The RNA sensor MDA5 detects SARS-CoV-2 infection.
Sampaio NG, Chauveau L, Hertzog J, Bridgeman A, Fowler G, Moonen JP, Dupont M, Russell RA, Noerenberg M, Rehwinkel J. Sampaio NG, et al. Among authors: rehwinkel j. Sci Rep. 2021 Jul 1;11(1):13638. doi: 10.1038/s41598-021-92940-3. Sci Rep. 2021. PMID: 34211037 Free PMC article.
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang HD, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK. Olagnier D, et al. Among authors: rehwinkel j. Nat Commun. 2020 Oct 2;11(1):4938. doi: 10.1038/s41467-020-18764-3. Nat Commun. 2020. PMID: 33009401 Free PMC article.
Regulation and inhibition of the DNA sensor cGAS.
Hertzog J, Rehwinkel J. Hertzog J, et al. Among authors: rehwinkel j. EMBO Rep. 2020 Dec 3;21(12):e51345. doi: 10.15252/embr.202051345. Epub 2020 Nov 5. EMBO Rep. 2020. PMID: 33155371 Free PMC article. Review.
Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.
Chauveau L, Bridgeman A, Tan TK, Beveridge R, Frost JN, Rijal P, Pedroza-Pacheco I, Partridge T, Gilbert-Jaramillo J, Knight ML, Liu X, Russell RA, Borrow P, Drakesmith H, Townsend AR, Rehwinkel J. Chauveau L, et al. Among authors: rehwinkel j. EMBO Rep. 2021 Aug 4;22(8):e52447. doi: 10.15252/embr.202152447. Epub 2021 Jun 18. EMBO Rep. 2021. PMID: 34142428 Free PMC article.
Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.
Hertzog J, Zhou W, Fowler G, Rigby RE, Bridgeman A, Blest HT, Cursi C, Chauveau L, Davenne T, Warner BE, Kinchington PR, Kranzusch PJ, Rehwinkel J. Hertzog J, et al. Among authors: rehwinkel j. EMBO J. 2022 Jul 18;41(14):e109217. doi: 10.15252/embj.2021109217. Epub 2022 Jun 7. EMBO J. 2022. PMID: 35670106 Free PMC article.
94 results