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Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z. Murashige D, et al. Among authors: hoshino a. Cell Metab. 2022 Nov 1;34(11):1749-1764.e7. doi: 10.1016/j.cmet.2022.09.008. Epub 2022 Oct 11. Cell Metab. 2022. PMID: 36223763 Free PMC article.
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. Jang C, et al. Among authors: hoshino a. Nat Med. 2016 Apr;22(4):421-6. doi: 10.1038/nm.4057. Epub 2016 Mar 7. Nat Med. 2016. PMID: 26950361 Free PMC article.
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z. Hoshino A, et al. Nature. 2019 Nov;575(7782):375-379. doi: 10.1038/s41586-019-1667-4. Epub 2019 Oct 16. Nature. 2019. PMID: 31618756 Free PMC article.
Activation of PPAR-α in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure.
Kaimoto S, Hoshino A, Ariyoshi M, Okawa Y, Tateishi S, Ono K, Uchihashi M, Fukai K, Iwai-Kanai E, Matoba S. Kaimoto S, et al. Among authors: hoshino a. Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H305-H313. doi: 10.1152/ajpheart.00553.2016. Epub 2016 Dec 23. Am J Physiol Heart Circ Physiol. 2017. PMID: 28011586 Free article.
An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis.
Hino T, Omura SN, Nakagawa R, Togashi T, Takeda SN, Hiramoto T, Tasaka S, Hirano H, Tokuyama T, Uosaki H, Ishiguro S, Kagieva M, Yamano H, Ozaki Y, Motooka D, Mori H, Kirita Y, Kise Y, Itoh Y, Matoba S, Aburatani H, Yachie N, Karvelis T, Siksnys V, Ohmori T, Hoshino A, Nureki O. Hino T, et al. Among authors: hoshino a. Cell. 2023 Oct 26;186(22):4920-4935.e23. doi: 10.1016/j.cell.2023.08.031. Epub 2023 Sep 29. Cell. 2023. PMID: 37776859 Free article.
565 results