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N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease.
Layburn FE, Tan AYS, Mehrabi NF, Curtis MA, Tippett LJ, Turner CP, Riguet N, Aeschbach L, Lashuel HA, Dragunow M, Faull RLM, Singh-Bains MK. Layburn FE, et al. Among authors: lashuel ha. Neurobiol Dis. 2022 Nov;174:105884. doi: 10.1016/j.nbd.2022.105884. Epub 2022 Oct 8. Neurobiol Dis. 2022. PMID: 36220612 Free article.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Hegde RN, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L, Auwerx J, Landles C, Bates GP, Singh-Bains MK, Dragunow M, Curtis MA, Faull RL, Ross CA, Caricasole A, Lashuel HA. Hegde RN, et al. Among authors: lashuel ha. EMBO J. 2020 Sep 1;39(17):e104671. doi: 10.15252/embj.2020104671. Epub 2020 Aug 5. EMBO J. 2020. PMID: 32757223 Free PMC article.
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology.
Kumar ST, Jagannath S, Francois C, Vanderstichele H, Stoops E, Lashuel HA. Kumar ST, et al. Among authors: lashuel ha. Neurobiol Dis. 2020 Dec;146:105086. doi: 10.1016/j.nbd.2020.105086. Epub 2020 Sep 22. Neurobiol Dis. 2020. PMID: 32971232 Free article.
222 results