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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts.
Karkhanis AV, Venkatesan G, Kambayashi R, Leow JWH, Han MQ, Izumi-Nakaseko H, Goto A, Pang JKS, Soh BS, Kojodjojo P, Sugiyama A, Chan ECY. Karkhanis AV, et al. Among authors: venkatesan g. Acta Pharm Sin B. 2022 Oct;12(10):3905-3923. doi: 10.1016/j.apsb.2022.03.008. Epub 2022 Mar 16. Acta Pharm Sin B. 2022. PMID: 36213535 Free PMC article.
Plasma Metabonomic Profiling of Diabetic Retinopathy.
Chen L, Cheng CY, Choi H, Ikram MK, Sabanayagam C, Tan GS, Tian D, Zhang L, Venkatesan G, Tai ES, Wang JJ, Mitchell P, Cheung CM, Beuerman RW, Zhou L, Chan EC, Wong TY. Chen L, et al. Among authors: venkatesan g. Diabetes. 2016 Apr;65(4):1099-108. doi: 10.2337/db15-0661. Epub 2016 Jan 28. Diabetes. 2016. PMID: 26822086
How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.
Kambayashi R, Hagiwara-Nagasawa M, Kondo Y, Yeo ZJ, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Leow JWH, Venkatesan G, Matsumoto A, Chan ECY, Sugiyama A. Kambayashi R, et al. Among authors: venkatesan g. Cardiovasc Toxicol. 2020 Aug;20(4):339-350. doi: 10.1007/s12012-019-09559-0. Cardiovasc Toxicol. 2020. PMID: 31898152
An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation.
Kambayashi R, Goto A, Nunoi Y, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Venkatesan G, Takei Y, Matsumoto A, Chan ECY, Sugiyama A. Kambayashi R, et al. Among authors: venkatesan g. Naunyn Schmiedebergs Arch Pharmacol. 2021 Jun;394(6):1103-1112. doi: 10.1007/s00210-020-02047-1. Epub 2021 Jan 11. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 33427928
142 results