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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts.
Karkhanis AV, Venkatesan G, Kambayashi R, Leow JWH, Han MQ, Izumi-Nakaseko H, Goto A, Pang JKS, Soh BS, Kojodjojo P, Sugiyama A, Chan ECY. Karkhanis AV, et al. Among authors: sugiyama a. Acta Pharm Sin B. 2022 Oct;12(10):3905-3923. doi: 10.1016/j.apsb.2022.03.008. Epub 2022 Mar 16. Acta Pharm Sin B. 2022. PMID: 36213535 Free PMC article.
Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.
Ito M, Yamanashi Y, Toyoda Y, Izumi-Nakaseko H, Oda S, Sugiyama A, Kuroda M, Suzuki H, Takada T, Adachi-Akahane S. Ito M, et al. Among authors: sugiyama a. Biochim Biophys Acta. 2013 Feb;1831(2):459-68. doi: 10.1016/j.bbalip.2012.11.008. Epub 2012 Nov 28. Biochim Biophys Acta. 2013. PMID: 23200860
Analysis of Onset Mechanisms of a Sphingosine 1-Phosphate Receptor Modulator Fingolimod-Induced Atrioventricular Conduction Block and QT-Interval Prolongation.
Yagi Y, Nakamura Y, Kitahara K, Harada T, Kato K, Ninomiya T, Cao X, Ohara H, Izumi-Nakaseko H, Suzuki K, Ando K, Sugiyama A. Yagi Y, et al. Among authors: sugiyama a. Toxicol Appl Pharmacol. 2014 Nov 15;281(1):39-47. doi: 10.1016/j.taap.2014.09.006. Epub 2014 Sep 16. Toxicol Appl Pharmacol. 2014. PMID: 25223691
Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models.
Watanabe Y, Nakamura Y, Cao X, Ohara H, Yamazaki Y, Murayama N, Sugiyama Y, Izumi-Nakaseko H, Ando K, Yamazaki H, Sugiyama A. Watanabe Y, et al. Among authors: sugiyama a, sugiyama y. Basic Clin Pharmacol Toxicol. 2015 Jun;116(6):468-75. doi: 10.1111/bcpt.12343. Epub 2014 Nov 22. Basic Clin Pharmacol Toxicol. 2015. PMID: 25370785 Free article.
Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.
Katagi J, Nakamura Y, Cao X, Ohara H, Honda A, Izumi-Nakaseko H, Ando K, Sugiyama A. Katagi J, et al. Among authors: sugiyama a. Cardiovasc Toxicol. 2016 Apr;16(2):138-46. doi: 10.1007/s12012-015-9322-2. Cardiovasc Toxicol. 2016. PMID: 25822712
1,141 results