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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts.
Karkhanis AV, Venkatesan G, Kambayashi R, Leow JWH, Han MQ, Izumi-Nakaseko H, Goto A, Pang JKS, Soh BS, Kojodjojo P, Sugiyama A, Chan ECY. Karkhanis AV, et al. Among authors: goto a. Acta Pharm Sin B. 2022 Oct;12(10):3905-3923. doi: 10.1016/j.apsb.2022.03.008. Epub 2022 Mar 16. Acta Pharm Sin B. 2022. PMID: 36213535 Free PMC article.
In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs.
Motokawa Y, Nakamura Y, Hagiwara-Nagasawa M, Goto A, Chiba K, Lubna NJ, Izumi-Nakaseko H, Ando K, Naito AT, Yamazaki H, Sugiyama A. Motokawa Y, et al. Among authors: goto a. Cardiovasc Toxicol. 2018 Jun;18(3):242-251. doi: 10.1007/s12012-017-9434-y. Cardiovasc Toxicol. 2018. PMID: 29139031
Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs.
Ando K, Takahara A, Nakamura Y, Wada T, Chiba K, Goto A, Lubna NJ, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Hoshiai K, Akie Y, Naito AT, Sugiyama A. Ando K, et al. Among authors: goto a. J Pharmacol Sci. 2018 Feb;136(2):86-92. doi: 10.1016/j.jphs.2018.01.002. Epub 2018 Feb 2. J Pharmacol Sci. 2018. PMID: 29398450 Free article.
Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine.
Ando K, Nakamura Y, Hagiwara-Nagasawa M, Harada H, Miyamoto H, Inamura N, Takagi K, Goto A, Chiba K, Lubna NJ, Izumi-Nakaseko H, Naito AT, Sugiyama A. Ando K, et al. Among authors: goto a. J Toxicol Sci. 2018;43(3):183-192. doi: 10.2131/jts.43.183. J Toxicol Sci. 2018. PMID: 29540652 Free article.
Effects of moxifloxacin on the proarrhythmic surrogate markers in healthy Filipino subjects: Exposure-response modeling using ECG data of thorough QT/QTc study.
Matsukura S, Nakamura Y, Hoshiai K, Hayashi T, Koga T, Goto A, Chiba K, Lubna NJ, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Naito AT, Sugiyama A. Matsukura S, et al. Among authors: goto a. J Pharmacol Sci. 2018 Apr;136(4):234-241. doi: 10.1016/j.jphs.2018.01.009. Epub 2018 Mar 27. J Pharmacol Sci. 2018. PMID: 29627227 Free article.
1,739 results