Chan ECY - Search Results

1

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts.

Karkhanis AV, Venkatesan G, Kambayashi R, Leow JWH, Han MQ, Izumi-Nakaseko H, Goto A, Pang JKS, Soh BS, Kojodjojo P, Sugiyama A, Chan ECY. Karkhanis AV, et al. Among authors: chan ecy. Acta Pharm Sin B. 2022 Oct;12(10):3905-3923. doi: 10.1016/j.apsb.2022.03.008. Epub 2022 Mar 16. Acta Pharm Sin B. 2022. PMID: 36213535 Free PMC article.

2

Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone.

Hong Y, Chia YM, Yeo RH, Venkatesan G, Koh SK, Chai CL, Zhou L, Kojodjojo P, Chan EC. Hong Y, et al. Mol Pharmacol. 2016 Jan;89(1):1-13. doi: 10.1124/mol.115.100891. Epub 2015 Oct 21. Mol Pharmacol. 2016. PMID: 26490246

3

Plasma Metabonomic Profiling of Diabetic Retinopathy.

Chen L, Cheng CY, Choi H, Ikram MK, Sabanayagam C, Tan GS, Tian D, Zhang L, Venkatesan G, Tai ES, Wang JJ, Mitchell P, Cheung CM, Beuerman RW, Zhou L, Chan EC, Wong TY. Chen L, et al. Diabetes. 2016 Apr;65(4):1099-108. doi: 10.2337/db15-0661. Epub 2016 Jan 28. Diabetes. 2016. PMID: 26822086

4

Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.

Karkhanis A, Lam HY, Venkatesan G, Koh SK, Chai CL, Zhou L, Hong Y, Kojodjojo P, Chan EC. Karkhanis A, et al. Biochem Pharmacol. 2016 May 1;107:67-80. doi: 10.1016/j.bcp.2016.03.005. Epub 2016 Mar 10. Biochem Pharmacol. 2016. PMID: 26972388

5

Application of Static Modeling --in the Prediction of In Vivo Drug-Drug Interactions between Rivaroxaban and Antiarrhythmic Agents Based on In Vitro Inhibition Studies.

Cheong EJ, Goh JJ, Hong Y, Venkatesan G, Liu Y, Chiu GN, Kojodjojo P, Chan EC. Cheong EJ, et al. Drug Metab Dispos. 2017 Mar;45(3):260-268. doi: 10.1124/dmd.116.073890. Epub 2017 Jan 4. Drug Metab Dispos. 2017. PMID: 28053220

6

Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy.

Karkhanis A, Hong Y, Chan ECY. Karkhanis A, et al. Among authors: chan ecy. Biochem Pharmacol. 2017 Jul 1;135:12-21. doi: 10.1016/j.bcp.2017.02.017. Epub 2017 Feb 23. Biochem Pharmacol. 2017. PMID: 28237650 Review.

7

Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.

Karkhanis A, Tram NDT, Chan ECY. Karkhanis A, et al. Among authors: chan ecy. Biochem Pharmacol. 2017 Dec 15;146:188-198. doi: 10.1016/j.bcp.2017.09.012. Epub 2017 Sep 25. Biochem Pharmacol. 2017. PMID: 28958841

8

Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids.

Karkhanis A, Leow JWH, Hagen T, Chan ECY. Karkhanis A, et al. Among authors: chan ecy. Toxicol Sci. 2018 May 1;163(1):79-91. doi: 10.1093/toxsci/kfy011. Toxicol Sci. 2018. PMID: 29385569

9

Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition.

Leow JWH, Chan ECY. Leow JWH, et al. Among authors: chan ecy. Biochem Pharmacol. 2019 Nov;169:113615. doi: 10.1016/j.bcp.2019.08.017. Epub 2019 Aug 21. Biochem Pharmacol. 2019. PMID: 31445022 Review.

10

How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.

Kambayashi R, Hagiwara-Nagasawa M, Kondo Y, Yeo ZJ, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Leow JWH, Venkatesan G, Matsumoto A, Chan ECY, Sugiyama A. Kambayashi R, et al. Among authors: chan ecy. Cardiovasc Toxicol. 2020 Aug;20(4):339-350. doi: 10.1007/s12012-019-09559-0. Cardiovasc Toxicol. 2020. PMID: 31898152

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