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A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo.
Suchowerska AK, Stokman G, Palmer JT, Coghlan PA, Pieterman EJ, Keijzer N, Lambert G, Chemello K, Jaafar AK, Parmar J, Yan L, Tong Y, Mu L, Princen HMG, Bonnar J, Evison BJ. Suchowerska AK, et al. Among authors: lambert g. J Lipid Res. 2022 Nov;63(11):100293. doi: 10.1016/j.jlr.2022.100293. Epub 2022 Oct 6. J Lipid Res. 2022. PMID: 36209894 Free PMC article.
A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.
Evison BJ, Palmer JT, Lambert G, Treutlein H, Zeng J, Nativel B, Chemello K, Zhu Q, Wang J, Teng Y, Tang W, Xu Y, Rathi AK, Kumar S, Suchowerska AK, Parmar J, Dixon I, Kelly GE, Bonnar J. Evison BJ, et al. Among authors: lambert g. Bioorg Med Chem. 2020 Mar 15;28(6):115344. doi: 10.1016/j.bmc.2020.115344. Epub 2020 Jan 31. Bioorg Med Chem. 2020. PMID: 32051094 Free article.
Heart to heart with PCSK9.
Chemello K, Jaafar AK, Lambert G. Chemello K, et al. Among authors: lambert g. Eur Heart J. 2021 Aug 21;42(32):3091-3093. doi: 10.1093/eurheartj/ehab480. Eur Heart J. 2021. PMID: 34324660 No abstract available.
PCSK9: from biology to clinical applications.
Blanchard V, Khantalin I, Ramin-Mangata S, Chémello K, Nativel B, Lambert G. Blanchard V, et al. Among authors: lambert g. Pathology. 2019 Feb;51(2):177-183. doi: 10.1016/j.pathol.2018.10.012. Epub 2018 Dec 4. Pathology. 2019. PMID: 30522786 Review.
Lipoprotein metabolism in familial hypercholesterolemia.
Chemello K, García-Nafría J, Gallo A, Martín C, Lambert G, Blom D. Chemello K, et al. Among authors: lambert g. J Lipid Res. 2021;62:100062. doi: 10.1016/j.jlr.2021.100062. Epub 2021 Mar 3. J Lipid Res. 2021. PMID: 33675717 Free PMC article. Review.
PCSK9 inhibition for autosomal recessive hypercholesterolemia.
Chemello K, Martín C, Lambert G. Chemello K, et al. Among authors: lambert g. Atherosclerosis. 2019 May;284:209-211. doi: 10.1016/j.atherosclerosis.2019.02.013. Epub 2019 Feb 23. Atherosclerosis. 2019. PMID: 30862376 No abstract available.
1,312 results