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Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery.
Chang L, Campbell J, Raji IO, Guduru SKR, Kandel P, Nguyen M, Liu S, Tran K, Venugopal NK, Taylor BC, Holt MV, Young NL, Samuel ELG, Jain P, Santini C, Sankaran B, MacKenzie KR, Young DW. Chang L, et al. Among authors: mackenzie kr. Sci Rep. 2021 Jan 13;11(1):1121. doi: 10.1038/s41598-020-80588-4. Sci Rep. 2021. PMID: 33441849 Free PMC article.
Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice.
Qin X, Hakenjos JM, MacKenzie KR, Barzi M, Chavan H, Nyshadham P, Wang J, Jung SY, Guner JZ, Chen S, Guo L, Krishnamurthy P, Bissig KD, Palmer S, Matzuk MM, Li F. Qin X, et al. Among authors: mackenzie kr. Drug Metab Dispos. 2022 Feb;50(2):128-139. doi: 10.1124/dmd.121.000633. Epub 2021 Nov 16. Drug Metab Dispos. 2022. PMID: 34785568 Free PMC article.
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.
Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Jiménez-Panizo A, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Estébanez-Perpiñá E, Venken K, Moore DD, Young DW, Maletic-Savatic M. Kandel P, et al. Among authors: mackenzie kr. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2023784119. doi: 10.1073/pnas.2023784119. Epub 2022 Mar 25. Proc Natl Acad Sci U S A. 2022. PMID: 35333654 Free PMC article.
104 results