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Antigen-specific depletion of CD4+ T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity.
Yi J, Miller AT, Archambault AS, Jones AJ, Bradstreet TR, Bandla S, Hsu YS, Edelson BT, Zhou YW, Fremont DH, Egawa T, Singh N, Wu GF, Hsieh CS. Yi J, et al. Among authors: hsu ys. Sci Immunol. 2022 Oct 14;7(76):eabo0777. doi: 10.1126/sciimmunol.abo0777. Epub 2022 Oct 7. Sci Immunol. 2022. PMID: 36206355 Free PMC article.
Antigen glycosylation regulates efficacy of CAR T cells targeting CD19.
Heard A, Landmann JH, Hansen AR, Papadopolou A, Hsu YS, Selli ME, Warrington JM, Lattin J, Chang J, Ha H, Haug-Kroeper M, Doray B, Gill S, Ruella M, Hayer KE, Weitzman MD, Green AM, Fluhrer R, Singh N. Heard A, et al. Among authors: hsu ys. Nat Commun. 2022 Jun 11;13(1):3367. doi: 10.1038/s41467-022-31035-7. Nat Commun. 2022. PMID: 35690611 Free PMC article.
Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction.
Selli ME, Landmann JH, Terekhova M, Lattin J, Heard A, Hsu YS, Chang TC, Chang J, Warrington J, Ha H, Kingston N, Hogg G, Slade M, Berrien-Elliott MM, Foster M, Kersting-Schadek S, Gruszczynska A, DeNardo D, Fehniger TA, Artyomov M, Singh N. Selli ME, et al. Among authors: hsu ys. Blood. 2023 Jun 29;141(26):3153-3165. doi: 10.1182/blood.2023020100. Blood. 2023. PMID: 37130030 Free PMC article.
Rational protein engineering to enhance MHC-independent T cell receptors.
Chang JF, Landmann JH, Chang TC, Selli ME, Tenzin Y, Warrington JM, Ritchey J, Hsu YS, Slade M, Gupta DK, DiPersio JF, Holehouse AS, Singh N. Chang JF, et al. Among authors: hsu ys. Cancer Discov. 2024 Jul 10. doi: 10.1158/2159-8290.CD-23-1393. Online ahead of print. Cancer Discov. 2024. PMID: 38980802
Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction.
Selli ME, Landmann JH, Terekhova M, Lattin J, Heard A, Hsu YS, Chang TC, Chang J, Warrington J, Ha H, Kingston N, Hogg G, Slade M, Berrien-Elliot MM, Foster M, Kersting-Schadek S, Gruszczynska A, DeNardo D, Fehniger TA, Artyomov M, Singh N. Selli ME, et al. Among authors: hsu ys. bioRxiv [Preprint]. 2023 Jan 27:2023.01.26.525725. doi: 10.1101/2023.01.26.525725. bioRxiv. 2023. Update in: Blood. 2023 Jun 29;141(26):3153-3165. doi: 10.1182/blood.2023020100. PMID: 36747791 Free PMC article. Updated. Preprint.
168 results