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SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.
Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D. Chen XW, et al. Elife. 2013 Apr 9;2:e00444. doi: 10.7554/eLife.00444. Elife. 2013. PMID: 23580231 Free PMC article.
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
Wang X, Wang H, Xu B, Huang D, Nie C, Pu L, Zajac GJM, Yan H, Zhao J, Shi F, Emmer BT, Lu J, Wang R, Dong X, Dai J, Zhou W, Wang C, Gao G, Wang Y, Willer C, Lu X, Zhu Y, Chen XW. Wang X, et al. Among authors: chen xw. Cell Metab. 2021 Feb 2;33(2):350-366.e7. doi: 10.1016/j.cmet.2020.10.020. Epub 2020 Nov 12. Cell Metab. 2021. PMID: 33186557 Free article.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW. Huang D, et al. Among authors: chen j, chen xw, chen fj. Cell Metab. 2021 Aug 3;33(8):1655-1670.e8. doi: 10.1016/j.cmet.2021.05.006. Epub 2021 May 19. Cell Metab. 2021. PMID: 34015269 Free article.
In vitro and in vivo assay of the ER lipid scramblase TMEM41B.
Wu L, Liu L, Xu B, Huang D, Chen XW. Wu L, et al. Among authors: chen xw. STAR Protoc. 2022 Apr 19;3(2):101333. doi: 10.1016/j.xpro.2022.101333. eCollection 2022 Jun 17. STAR Protoc. 2022. PMID: 35496801 Free PMC article.
949 results