Faller B - Search Results

1

Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects.

Poller B, Werner S, Domange N, Mettler L, Stein RR, Loretan J, Wartmann M, Faller B, Huth F. Poller B, et al. Among authors: faller b. Xenobiotica. 2022 Aug;52(8):878-889. doi: 10.1080/00498254.2022.2130837. Xenobiotica. 2022. PMID: 36189672

2

Predicting Oral Absorption for Compounds Outside the Rule of Five Property Space.

Huth F, Domange N, Poller B, Vapurcuyan A, Durrwell A, Hanna ID, Faller B. Huth F, et al. Among authors: faller b. J Pharm Sci. 2021 Jun;110(6):2562-2569. doi: 10.1016/j.xphs.2021.01.029. Epub 2021 Feb 1. J Pharm Sci. 2021. PMID: 33539870

3

CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs.

Zimmerlin A, Trunzer M, Faller B. Zimmerlin A, et al. Among authors: faller b. Drug Metab Dispos. 2011 Jun;39(6):1039-46. doi: 10.1124/dmd.110.037911. Epub 2011 Mar 7. Drug Metab Dispos. 2011. PMID: 21383203

4

Modeling promiscuity based on in vitro safety pharmacology profiling data.

Azzaoui K, Hamon J, Faller B, Whitebread S, Jacoby E, Bender A, Jenkins JL, Urban L. Azzaoui K, et al. Among authors: faller b. ChemMedChem. 2007 Jun;2(6):874-80. doi: 10.1002/cmdc.200700036. ChemMedChem. 2007. PMID: 17492703

5

Evaluation of the GastroPlus™ Advanced Compartmental and Transit (ACAT) Model in Early Discovery.

Gobeau N, Stringer R, De Buck S, Tuntland T, Faller B. Gobeau N, et al. Among authors: faller b. Pharm Res. 2016 Sep;33(9):2126-39. doi: 10.1007/s11095-016-1951-z. Epub 2016 Jun 8. Pharm Res. 2016. PMID: 27278908

6

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.

Wohnsland F, Faller B. Wohnsland F, et al. Among authors: faller b. J Med Chem. 2001 Mar 15;44(6):923-30. doi: 10.1021/jm001020e. J Med Chem. 2001. PMID: 11300874

7

High-throughput lipophilicity measurement with immobilized artificial membranes.

Faller B, Grimm HP, Loeuillet-Ritzler F, Arnold S, Briand X. Faller B, et al. J Med Chem. 2005 Apr 7;48(7):2571-6. doi: 10.1021/jm049377w. J Med Chem. 2005. PMID: 15801846

8

Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.

Trunzer M, Faller B, Zimmerlin A. Trunzer M, et al. Among authors: faller b. J Med Chem. 2009 Jan 22;52(2):329-35. doi: 10.1021/jm8008663. J Med Chem. 2009. PMID: 19108654

9

Benefit of Retraining pKa Models Studied Using Internally Measured Data.

Gedeck P, Lu Y, Skolnik S, Rodde S, Dollinger G, Jia W, Berellini G, Vianello R, Faller B, Lombardo F. Gedeck P, et al. Among authors: faller b. J Chem Inf Model. 2015 Jul 27;55(7):1449-59. doi: 10.1021/acs.jcim.5b00172. Epub 2015 Jun 29. J Chem Inf Model. 2015. PMID: 26052622

10

High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.

Faller B, Wang J, Zimmerlin A, Bell L, Hamon J, Whitebread S, Azzaoui K, Bojanic D, Urban L. Faller B, et al. Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):823-33. doi: 10.1517/17425255.2.6.823. Expert Opin Drug Metab Toxicol. 2006. PMID: 17125403 Review.

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