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A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.
Qiu D, Pei JV, Rosling JEO, Thathy V, Li D, Xue Y, Tanner JD, Penington JS, Aw YTV, Aw JYH, Xu G, Tripathi AK, Gnadig NF, Yeo T, Fairhurst KJ, Stokes BH, Murithi JM, Kümpornsin K, Hasemer H, Dennis ASM, Ridgway MC, Schmitt EK, Straimer J, Papenfuss AT, Lee MCS, Corry B, Sinnis P, Fidock DA, van Dooren GG, Kirk K, Lehane AM. Qiu D, et al. Among authors: stokes bh. Nat Commun. 2022 Sep 30;13(1):5746. doi: 10.1038/s41467-022-33403-9. Nat Commun. 2022. PMID: 36180431 Free PMC article.
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites.
Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, Terrell SM, Boucher MJ, Cieplak P, Kumpornsin K, Lee MCS, Linington RG, Long JZ, Uhlemann AC, Weerapana E, Fidock DA, Bogyo M. Yoo E, et al. Among authors: stokes bh. Cell Chem Biol. 2020 Feb 20;27(2):143-157.e5. doi: 10.1016/j.chembiol.2020.01.001. Epub 2020 Jan 23. Cell Chem Biol. 2020. PMID: 31978322 Free PMC article.
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Gnädig NF, Stokes BH, Edwards RL, Kalantarov GF, Heimsch KC, Kuderjavy M, Crane A, Lee MCS, Straimer J, Becker K, Trakht IN, Odom John AR, Mok S, Fidock DA. Gnädig NF, et al. Among authors: stokes bh. PLoS Pathog. 2020 Apr 20;16(4):e1008482. doi: 10.1371/journal.ppat.1008482. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32310999 Free PMC article.
Evidence of Artemisinin-Resistant Malaria in Africa.
Stokes BH, Ward KE, Fidock DA. Stokes BH, et al. N Engl J Med. 2022 Apr 7;386(14):1385-1386. doi: 10.1056/NEJMc2117480. N Engl J Med. 2022. PMID: 35388682 Free PMC article. No abstract available.
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Stokes BH, Dhingra SK, Rubiano K, Mok S, Straimer J, Gnädig NF, Deni I, Schindler KA, Bath JR, Ward KE, Striepen J, Yeo T, Ross LS, Legrand E, Ariey F, Cunningham CH, Souleymane IM, Gansané A, Nzoumbou-Boko R, Ndayikunda C, Kabanywanyi AM, Uwimana A, Smith SJ, Kolley O, Ndounga M, Warsame M, Leang R, Nosten F, Anderson TJ, Rosenthal PJ, Ménard D, Fidock DA. Stokes BH, et al. Elife. 2021 Jul 19;10:e66277. doi: 10.7554/eLife.66277. Elife. 2021. PMID: 34279219 Free PMC article.
28 results