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A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.
Qiu D, Pei JV, Rosling JEO, Thathy V, Li D, Xue Y, Tanner JD, Penington JS, Aw YTV, Aw JYH, Xu G, Tripathi AK, Gnadig NF, Yeo T, Fairhurst KJ, Stokes BH, Murithi JM, Kümpornsin K, Hasemer H, Dennis ASM, Ridgway MC, Schmitt EK, Straimer J, Papenfuss AT, Lee MCS, Corry B, Sinnis P, Fidock DA, van Dooren GG, Kirk K, Lehane AM. Qiu D, et al. Among authors: ridgway mc. Nat Commun. 2022 Sep 30;13(1):5746. doi: 10.1038/s41467-022-33403-9. Nat Commun. 2022. PMID: 36180431 Free PMC article.
Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen - A cautionary tale in screening transgenic parasites.
Tran PN, Tate CJ, Ridgway MC, Saliba KJ, Kirk K, Maier AG. Tran PN, et al. Among authors: ridgway mc. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):179-183. doi: 10.1016/j.ijpddr.2016.09.003. Epub 2016 Sep 22. Int J Parasitol Drugs Drug Resist. 2016. PMID: 27705841 Free PMC article.
26 results