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Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.
Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, Newton AC. Pilo CA, et al. Among authors: baffi tr. Sci Signal. 2022 Sep 27;15(753):eabk1147. doi: 10.1126/scisignal.abk1147. Epub 2022 Sep 27. Sci Signal. 2022. PMID: 36166510 Free PMC article.
Protein kinase C: release from quarantine by mTORC2.
Baffi TR, Newton AC. Baffi TR, et al. Trends Biochem Sci. 2022 Jun;47(6):518-530. doi: 10.1016/j.tibs.2022.03.003. Epub 2022 Mar 28. Trends Biochem Sci. 2022. PMID: 35361526 Free PMC article. Review.
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.
Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N. Huang LC, et al. Among authors: baffi tr. Sci Rep. 2018 Apr 25;8(1):6518. doi: 10.1038/s41598-018-24457-1. Sci Rep. 2018. PMID: 29695735 Free PMC article.