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Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Gupta PK, Allocco JB, Fraipont JM, McKeague ML, Wang P, Andrade MS, McIntosh C, Chen L, Wang Y, Li Y, Andrade J, Conejo-Garcia JR, Chong AS, Alegre ML. Gupta PK, et al. Among authors: chen l. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2205062119. doi: 10.1073/pnas.2205062119. Epub 2022 Sep 26. Proc Natl Acad Sci U S A. 2022. PMID: 36161903 Free PMC article.
TLR engagement prevents transplantation tolerance.
Chen L, Wang T, Zhou P, Ma L, Yin D, Shen J, Molinero L, Nozaki T, Phillips T, Uematsu S, Akira S, Wang CR, Fairchild RL, Alegre ML, Chong A. Chen L, et al. Am J Transplant. 2006 Oct;6(10):2282-91. doi: 10.1111/j.1600-6143.2006.01489.x. Am J Transplant. 2006. PMID: 16970798 Free article.
Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells.
Miller ML, Mashayekhi M, Chen L, Zhou P, Liu X, Michelotti M, Tramontini Gunn N, Powers S, Zhu X, Evaristo C, Alegre ML, Molinero LL. Miller ML, et al. Among authors: chen l. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7397-402. doi: 10.1073/pnas.1315398111. Epub 2014 May 5. Proc Natl Acad Sci U S A. 2014. PMID: 24799710 Free PMC article.
T cell-NF-κB activation is required for tumor control in vivo.
Barnes SE, Wang Y, Chen L, Molinero LL, Gajewski TF, Evaristo C, Alegre ML. Barnes SE, et al. Among authors: chen l. J Immunother Cancer. 2015 Jan 20;3(1):1. doi: 10.1186/s40425-014-0045-x. eCollection 2015. J Immunother Cancer. 2015. PMID: 25648675 Free PMC article.
High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Molinero LL, Yin D, Lei YM, Chen L, Wang Y, Chong AS, Alegre ML. Molinero LL, et al. Among authors: chen l. Transplantation. 2016 May;100(5):1015-21. doi: 10.1097/TP.0000000000001141. Transplantation. 2016. PMID: 27007226 Free PMC article.
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