Lu D - Search Results

1

Targeted Protein Degradation via Lysosomes.

Paudel RR, Lu D, Roy Chowdhury S, Monroy EY, Wang J. Paudel RR, et al. Among authors: lu d. Biochemistry. 2023 Feb 7;62(3):564-579. doi: 10.1021/acs.biochem.2c00310. Epub 2022 Sep 21. Biochemistry. 2023. PMID: 36130224 Free PMC article. Review.

2

Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry.

Guo WH, Qi X, Yu X, Liu Y, Chung CI, Bai F, Lin X, Lu D, Wang L, Chen J, Su LH, Nomie KJ, Li F, Wang MC, Shu X, Onuchic JN, Woyach JA, Wang ML, Wang J. Guo WH, et al. Among authors: lu d. Nat Commun. 2020 Aug 26;11(1):4268. doi: 10.1038/s41467-020-17997-6. Nat Commun. 2020. PMID: 32848159 Free PMC article.

3

Development of improved SRC-3 inhibitors as breast cancer therapeutic agents.

Qin L, Chen J, Lu D, Jain P, Yu Y, Cardenas D, Peng X, Yu X, Xu J, Wang J, O'Malley BW, Lonard DM. Qin L, et al. Among authors: lu d. Endocr Relat Cancer. 2021 Aug 13;28(10):657-670. doi: 10.1530/ERC-20-0402. Endocr Relat Cancer. 2021. PMID: 34310341 Free PMC article.

4

Applications of covalent chemistry in targeted protein degradation.

Lu D, Yu X, Lin H, Cheng R, Monroy EY, Qi X, Wang MC, Wang J. Lu D, et al. Chem Soc Rev. 2022 Nov 14;51(22):9243-9261. doi: 10.1039/d2cs00362g. Chem Soc Rev. 2022. PMID: 36285735 Free PMC article. Review.

5

Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development.

Yu X, Guo WH, Lin H, Cheng R, Monroy EY, Jin F, Ding L, Lu D, Qi X, Wang MC, Wang J. Yu X, et al. Among authors: lu d. Curr Res Chem Biol. 2022;2:100029. doi: 10.1016/j.crchbi.2022.100029. Epub 2022 May 17. Curr Res Chem Biol. 2022. PMID: 36712232 Free PMC article.

6

Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma.

Bijou I, Liu Y, Lu D, Chen J, Sloan S, Alinari L, Lonard DM, O'Malley BW, Wang M, Wang J. Bijou I, et al. Among authors: lu d. Res Sq [Preprint]. 2023 Mar 10:rs.3.rs-2653461. doi: 10.21203/rs.3.rs-2653461/v1. Res Sq. 2023. Update in: PLoS One. 2024 Apr 29;19(4):e0289902. doi: 10.1371/journal.pone.0289902 PMID: 36945511 Free PMC article. Updated. Preprint.

7

Quantification of glutathione with high throughput live-cell imaging.

Qi X, Chen J, Jiang X, Lu D, Yu X, Lin H, Monroy EY, Wang MC, Wang J. Qi X, et al. Among authors: lu d. bioRxiv [Preprint]. 2023 Jul 12:2023.07.11.548586. doi: 10.1101/2023.07.11.548586. bioRxiv. 2023. PMID: 37503234 Free PMC article. Preprint.

8

Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors.

Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, Han D, Malmberg E, Chan DW, Wang X, Savage SR, Mao S, Yu J, Peng F, Yan L, Meng H, Maneix L, Han Y, Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X. Lv X, et al. Among authors: lu x, lu d. Science. 2023 Sep 8;381(6662):eabn4180. doi: 10.1126/science.abn4180. Epub 2023 Sep 8. Science. 2023. PMID: 37676964 Free PMC article.

9

Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy.

Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O'Malley BW, Lonard DM, Wang J. Lu D, et al. J Med Chem. 2024 Apr 11;67(7):5333-5350. doi: 10.1021/acs.jmedchem.3c01596. Epub 2024 Mar 29. J Med Chem. 2024. PMID: 38551814 Free PMC article.

10

Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma.

Bijou I, Liu Y, Lu D, Chen J, Sloan S, Alinari L, Lonard DM, O'Malley BW, Wang M, Wang J. Bijou I, et al. Among authors: lu d. PLoS One. 2024 Apr 29;19(4):e0289902. doi: 10.1371/journal.pone.0289902. eCollection 2024. PLoS One. 2024. PMID: 38683834 Free PMC article.

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