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Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355.
Kepplinger B, Mardiana L, Cowell J, Morton-Laing S, Dashti Y, Wills C, Marrs ECL, Perry JD, Gray J, Goodfellow M, Errington J, Probert MR, Clegg W, Bogaerts J, Herrebout W, Allenby NEE, Hall MJ. Kepplinger B, et al. Among authors: cowell j. Sci Rep. 2022 Sep 16;12(1):15579. doi: 10.1038/s41598-022-18726-3. Sci Rep. 2022. PMID: 36114335 Free PMC article.
Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease.
Cooper MS, Zhang L, Ibrahim M, Zhang K, Sun X, Röske J, Göhl M, Brönstrup M, Cowell JK, Sauerhering L, Becker S, Vangeel L, Jochmans D, Neyts J, Rox K, Marsh GP, Maple HJ, Hilgenfeld R. Cooper MS, et al. Among authors: cowell jk. J Med Chem. 2022 Oct 13;65(19):13328-13342. doi: 10.1021/acs.jmedchem.2c01131. Epub 2022 Sep 30. J Med Chem. 2022. PMID: 36179320 Free PMC article.
Targeting the WASF3 complex to suppress metastasis.
Limaye AJ, Whittaker MK, Bendzunas GN, Cowell JK, Kennedy EJ. Limaye AJ, et al. Among authors: cowell jk. Pharmacol Res. 2022 Aug;182:106302. doi: 10.1016/j.phrs.2022.106302. Epub 2022 Jun 9. Pharmacol Res. 2022. PMID: 35691539 Review.
521 results