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Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim.
Lee IK, Jacome DA, Cho JK, Tu V, Young AJ, Dominguez T, Northrup JD, Etersque JM, Lee HS, Ruff A, Aklilu O, Bittinger K, Glaser LJ, Dorgan D, Hadjiliadis D, Kohli RM, Mach RH, Mankoff DA, Doot RK, Sellmyer MA. Lee IK, et al. Among authors: northrup jd. J Clin Invest. 2022 Sep 15;132(18):e156679. doi: 10.1172/JCI156679. J Clin Invest. 2022. PMID: 36106638 Free PMC article.
Regulation of eDHFR-tagged proteins with trimethoprim PROTACs.
Etersque JM, Lee IK, Sharma N, Xu K, Ruff A, Northrup JD, Sarkar S, Nguyen T, Lauman R, Burslem GM, Sellmyer MA. Etersque JM, et al. Among authors: northrup jd. Nat Commun. 2023 Nov 3;14(1):7071. doi: 10.1038/s41467-023-42820-3. Nat Commun. 2023. PMID: 37923771 Free PMC article.
Development of Spiroligomer-Peptoid Hybrids.
Northrup JD, Mancini G, Purcell CR, Schafmeister CE. Northrup JD, et al. J Org Chem. 2017 Dec 15;82(24):13020-13033. doi: 10.1021/acs.joc.7b01956. Epub 2017 Dec 5. J Org Chem. 2017. PMID: 29161507
Metal-Binding Q-Proline Macrocycles.
Northrup JD, Wiener JA, Hurley MFD, Hou CD, Keller TM, Baxter RHG, Zdilla MJ, Voelz VA, Schafmeister CE. Northrup JD, et al. J Org Chem. 2021 Mar 19;86(6):4867-4876. doi: 10.1021/acs.joc.1c00116. Epub 2021 Feb 26. J Org Chem. 2021. PMID: 33635647