Coombes BK - Search Results

1

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.

Klobucar K, Jardine E, Farha MA, MacKinnon MR, Fragis M, Nkonge B, Bhando T, Borrillo L, Tsai CN, Johnson JW, Coombes BK, Magolan J, Brown ED. Klobucar K, et al. Among authors: coombes bk. ACS Infect Dis. 2022 Oct 14;8(10):2187-2197. doi: 10.1021/acsinfecdis.2c00357. Epub 2022 Sep 13. ACS Infect Dis. 2022. PMID: 36098580

2

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Ejim L, et al. Among authors: coombes bk. Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559. Epub 2011 Apr 24. Nat Chem Biol. 2011. PMID: 21516114

3

Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae.

Falconer SB, Reid-Yu SA, King AM, Gehrke SS, Wang W, Britten JF, Coombes BK, Wright GD, Brown ED. Falconer SB, et al. Among authors: coombes bk. ACS Infect Dis. 2015 Nov 13;1(11):533-43. doi: 10.1021/acsinfecdis.5b00033. Epub 2015 May 26. ACS Infect Dis. 2015. PMID: 27623408

4

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.

Stokes JM, MacNair CR, Ilyas B, French S, Côté JP, Bouwman C, Farha MA, Sieron AO, Whitfield C, Coombes BK, Brown ED. Stokes JM, et al. Among authors: coombes bk. Nat Microbiol. 2017 Mar 6;2:17028. doi: 10.1038/nmicrobiol.2017.28. Nat Microbiol. 2017. PMID: 28263303 Free PMC article.

5

Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome.

Ilyas B, Tsai CN, Coombes BK. Ilyas B, et al. Among authors: coombes bk. Front Cell Infect Microbiol. 2017 Sep 29;7:428. doi: 10.3389/fcimb.2017.00428. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 29034217 Free PMC article. Review.

6

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics.

MacNair CR, Stokes JM, Carfrae LA, Fiebig-Comyn AA, Coombes BK, Mulvey MR, Brown ED. MacNair CR, et al. Among authors: coombes bk. Nat Commun. 2018 Jan 31;9(1):458. doi: 10.1038/s41467-018-02875-z. Nat Commun. 2018. PMID: 29386620 Free PMC article.

7

Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium.

Ilyas B, Mulder DT, Little DJ, Elhenawy W, Banda MM, Pérez-Morales D, Tsai CN, Chau NYE, Bustamante VH, Coombes BK. Ilyas B, et al. Among authors: coombes bk. Cell Rep. 2018 Oct 23;25(4):825-832.e5. doi: 10.1016/j.celrep.2018.09.078. Cell Rep. 2018. PMID: 30355489 Free article.

8

Antibiotics Potentiate Adherent-Invasive E. coli Infection and Expansion.

Oberc AM, Fiebig-Comyn AA, Tsai CN, Elhenawy W, Coombes BK. Oberc AM, et al. Among authors: coombes bk. Inflamm Bowel Dis. 2019 Mar 14;25(4):711-721. doi: 10.1093/ibd/izy361. Inflamm Bowel Dis. 2019. PMID: 30496418

9

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium.

Ellis MJ, Tsai CN, Johnson JW, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Magolan J, Coombes BK, Brown ED. Ellis MJ, et al. Among authors: coombes bk. Nat Commun. 2019 Jan 14;10(1):197. doi: 10.1038/s41467-018-08190-x. Nat Commun. 2019. PMID: 30643129 Free PMC article.

10

Host-Specific Adaptive Diversification of Crohn's Disease-Associated Adherent-Invasive Escherichia coli.

Elhenawy W, Tsai CN, Coombes BK. Elhenawy W, et al. Among authors: coombes bk. Cell Host Microbe. 2019 Feb 13;25(2):301-312.e5. doi: 10.1016/j.chom.2018.12.010. Epub 2019 Jan 22. Cell Host Microbe. 2019. PMID: 30683582 Free article.

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