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Page 1
Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units.
Love SB, Cafferty F, Snowdon C, Carty K, Savage J, Pallmann P, McParland L, Brown L, Masters L, Schiavone F, Hague D, Townsend S, Amos C, South A, Sturgeon K, Langley R, Maughan T, James N, Hall E, Kernaghan S, Bliss J, Turner N, Tutt A, Yap C, Firth C, Kong A, Mehanna H, Watts C, Hills R, Thomas I, Copland M, Bell S, Sebag-Montefiore D, Jones R, Parmar MKB, Sydes MR. Love SB, et al. Among authors: brown l. Trials. 2022 Sep 6;23(1):757. doi: 10.1186/s13063-022-06680-4. Trials. 2022. PMID: 36068599 Free PMC article.
Evaluating many treatments and biomarkers in oncology: a new design.
Kaplan R, Maughan T, Crook A, Fisher D, Wilson R, Brown L, Parmar M. Kaplan R, et al. Among authors: brown l. J Clin Oncol. 2013 Dec 20;31(36):4562-8. doi: 10.1200/JCO.2013.50.7905. Epub 2013 Nov 18. J Clin Oncol. 2013. PMID: 24248692 Free PMC article.
PROMIS--Prostate MR imaging study: A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer.
El-Shater Bosaily A, Parker C, Brown LC, Gabe R, Hindley RG, Kaplan R, Emberton M, Ahmed HU; PROMIS Group. El-Shater Bosaily A, et al. Among authors: brown lc. Contemp Clin Trials. 2015 May;42:26-40. doi: 10.1016/j.cct.2015.02.008. Epub 2015 Mar 3. Contemp Clin Trials. 2015. PMID: 25749312 Free PMC article.
Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.
Parmar MK, Sydes MR, Cafferty FH, Choodari-Oskooei B, Langley RE, Brown L, Phillips PP, Spears MR, Rowley S, Kaplan R, James ND, Maughan T, Paton N, Royston PJ. Parmar MK, et al. Among authors: brown l. Clin Trials. 2017 Oct;14(5):451-461. doi: 10.1177/1740774517725697. Epub 2017 Aug 22. Clin Trials. 2017. PMID: 28830236 Free PMC article.
DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.
Cook JA, Julious SA, Sones W, Hampson LV, Hewitt C, Berlin JA, Ashby D, Emsley R, Fergusson DA, Walters SJ, Wilson ECF, Maclennan G, Stallard N, Rothwell JC, Bland M, Brown L, Ramsay CR, Cook A, Armstrong D, Altman D, Vale LD. Cook JA, et al. Among authors: brown l. Trials. 2018 Nov 5;19(1):606. doi: 10.1186/s13063-018-2884-0. Trials. 2018. PMID: 30400926 Free PMC article.
Mind the gap? The platform trial as a working environment.
Morrell L, Hordern J, Brown L, Sydes MR, Amos CL, Kaplan RS, Parmar MKB, Maughan TS. Morrell L, et al. Among authors: brown l. Trials. 2019 May 29;20(1):297. doi: 10.1186/s13063-019-3377-5. Trials. 2019. PMID: 31138284 Free PMC article.
Changing platforms without stopping the train: experiences of data management and data management systems when adapting platform protocols by adding and closing comparisons.
Hague D, Townsend S, Masters L, Rauchenberger M, Van Looy N, Diaz-Montana C, Gannon M, James N, Maughan T, Parmar MKB, Brown L, Sydes MR; STAMPEDE and FOCUS4 investigators. Hague D, et al. Among authors: brown l. Trials. 2019 May 29;20(1):294. doi: 10.1186/s13063-019-3322-7. Trials. 2019. PMID: 31138292 Free PMC article.
This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols.
Schiavone F, Bathia R, Letchemanan K, Masters L, Amos C, Bara A, Brown L, Gilson C, Pugh C, Atako N, Hudson F, Parmar M, Langley R, Kaplan RS, Parker C, Attard G, Clarke NW, Gillessen S, James ND, Maughan T, Sydes MR; past and present members of the STAMPEDE and FOCUS4 Trial Management Group. Schiavone F, et al. Among authors: brown l. Trials. 2019 May 29;20(1):264. doi: 10.1186/s13063-019-3216-8. Trials. 2019. PMID: 31138317 Free PMC article.
Biomarker-guided trials: Challenges in practice.
Antoniou M, Kolamunnage-Dona R, Wason J, Bathia R, Billingham C, Bliss JM, Brown LC, Gillman A, Paul J, Jorgensen AL. Antoniou M, et al. Among authors: brown lc. Contemp Clin Trials Commun. 2019 Nov 16;16:100493. doi: 10.1016/j.conctc.2019.100493. eCollection 2019 Dec. Contemp Clin Trials Commun. 2019. PMID: 31788574 Free PMC article.
Effective delivery of Complex Innovative Design (CID) cancer trials-A consensus statement.
Blagden SP, Billingham L, Brown LC, Buckland SW, Cooper AM, Ellis S, Fisher W, Hughes H, Keatley DA, Maignen FM, Morozov A, Navaie W, Pearson S, Shaaban A, Wydenbach K, Kearns PR; Experimental Cancer Medicine Centres (ECMC) CID trials working group. Blagden SP, et al. Among authors: brown lc. Br J Cancer. 2020 Feb;122(4):473-482. doi: 10.1038/s41416-019-0653-9. Epub 2020 Jan 6. Br J Cancer. 2020. PMID: 31907370 Free PMC article. Review.
7,805 results