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First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.
Prativadibhayankaram VS, Lee LS, Lye D, Xiaoying X, Nellore R, Pendharkar V, Hentze H, Guan S, Ayers BJ, Seah SGK, Chye H, Talib NSN, Kaliaperumal N, Ong WY, Wong ZX, Au VB, Alok A, Connolly JE, Boyd-Kirkup JD, Ingram PJ, Hanson BJ, Ethirajulu K, O'Connell D, Chan CEZ. Prativadibhayankaram VS, et al. Among authors: guan s. Infect Dis Ther. 2022 Oct;11(5):1999-2015. doi: 10.1007/s40121-022-00681-1. Epub 2022 Sep 4. Infect Dis Ther. 2022. PMID: 36058990 Free PMC article.
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody.
Chan CEZ, Seah SGK, Chye H, Massey S, Torres M, Lim APC, Wong SKK, Neo JJY, Wong PS, Lim JH, Loh GSL, Wang D, Boyd-Kirkup JD, Guan S, Thakkar D, Teo GH, Purushotorman K, Hutchinson PE, Young BE, Low JG, MacAry PA, Hentze H, Prativadibhayankara VS, Ethirajulu K, Comer JE, Tseng CK, Barrett ADT, Ingram PJ, Brasel T, Hanson BJ. Chan CEZ, et al. Among authors: guan s. PLoS One. 2021 Jun 23;16(6):e0253487. doi: 10.1371/journal.pone.0253487. eCollection 2021. PLoS One. 2021. PMID: 34161386 Free PMC article.
Rationally targeted anti-VISTA antibody that blockades the C-C' loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner.
Thakkar D, Paliwal S, Dharmadhikari B, Guan S, Liu L, Kar S, Tulsian NK, Gruber JJ, DiMascio L, Paszkiewicz KH, Ingram PJ, D Boyd-Kirkup J. Thakkar D, et al. Among authors: guan s. J Immunother Cancer. 2022 Feb;10(2):e003382. doi: 10.1136/jitc-2021-003382. J Immunother Cancer. 2022. PMID: 35131861 Free PMC article.
The oral microbiota: new insight into intracranial aneurysms.
Gong W, Yu H, You W, Chen Z, Wang Y, Liu C, Li Y, Guan S. Gong W, et al. Among authors: guan s. Ann Med. 2025 Dec;57(1):2451191. doi: 10.1080/07853890.2025.2451191. Epub 2025 Jan 13. Ann Med. 2025. PMID: 39803910 Free PMC article. Review.
2,523 results