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Page 1
Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity.
Kim KM, Mura-Meszaros A, Tollot M, Krishnan MS, Gründl M, Neubert L, Groth M, Rodriguez-Fraticelli A, Svendsen AF, Campaner S, Andreas N, Kamradt T, Hoffmann S, Camargo FD, Heidel FH, Bystrykh LV, de Haan G, von Eyss B. Kim KM, et al. Among authors: svendsen af. Nat Commun. 2022 Sep 3;13(1):5187. doi: 10.1038/s41467-022-32970-1. Nat Commun. 2022. PMID: 36057685 Free PMC article.
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N, Trumpp A. Renders S, et al. Among authors: svendsen af. Nat Commun. 2021 Jan 27;12(1):608. doi: 10.1038/s41467-020-20801-0. Nat Commun. 2021. PMID: 33504783 Free PMC article.
Elevated granulocyte-colony stimulating factor and hematopoietic stem cell mobilization in Niemann-Pick type C1 disease.
Groenen AG, La Rose AM, Li M, Bazioti V, Svendsen AF, Kloosterhuis NJ, Ausema A, Pranger A, Heiner-Fokkema MR, Niezen-Koning KE, Houben T, Shiri-Sverdlov R, Westerterp M. Groenen AG, et al. Among authors: svendsen af. J Lipid Res. 2022 Feb;63(2):100167. doi: 10.1016/j.jlr.2021.100167. Epub 2022 Jan 8. J Lipid Res. 2022. PMID: 35007562 Free PMC article.
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.
Mitchell CA, Verovskaya EV, Calero-Nieto FJ, Olson OC, Swann JW, Wang X, Hérault A, Dellorusso PV, Zhang SY, Svendsen AF, Pietras EM, Bakker ST, Ho TT, Göttgens B, Passegué E. Mitchell CA, et al. Among authors: svendsen af. Nat Cell Biol. 2023 Jan;25(1):30-41. doi: 10.1038/s41556-022-01053-0. Epub 2023 Jan 17. Nat Cell Biol. 2023. PMID: 36650381 Free PMC article.
LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endotheliums.
Zhang H, Hansen M, Di Summa F, Von Lindern M, Gillemans N, Van IJcken WFJ, Svendsen AF, Philipsen S, Van der Reijden B, Varga E, Van den Akker E. Zhang H, et al. Among authors: svendsen af. Haematologica. 2024 Jul 4. doi: 10.3324/haematol.2024.285214. Online ahead of print. Haematologica. 2024. PMID: 38961746 Free article.
Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans.
Loaiza N, Hartgers ML, Reeskamp LF, Balder JW, Rimbert A, Bazioti V, Wolters JC, Winkelmeijer M, Jansen HPG, Dallinga-Thie GM, Volta A, Huijkman N, Smit M, Kloosterhuis N, Koster M, Svendsen AF, van de Sluis B, Hovingh GK, Grefhorst A, Kuivenhoven JA. Loaiza N, et al. Among authors: svendsen af. Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):973-985. doi: 10.1161/ATVBAHA.119.313470. Epub 2020 Jan 30. Arterioscler Thromb Vasc Biol. 2020. PMID: 31996024 Free PMC article.
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.
La Rose AM, Bazioti V, Hoogerland JA, Svendsen AF, Groenen AG, van Faassen M, Rutten MGS, Kloosterhuis NJ, Dethmers-Ausema B, Nijland JH, Mithieux G, Rajas F, Kuipers F, Lukens MV, Soehnlein O, Oosterveer MH, Westerterp M. La Rose AM, et al. Among authors: svendsen af. Mol Metab. 2021 Nov;53:101265. doi: 10.1016/j.molmet.2021.101265. Epub 2021 Jun 4. Mol Metab. 2021. PMID: 34091064 Free PMC article.
CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness genes and can be targeted by the BCL2 inhibitor venetoclax.
Mattes K, Gerritsen M, Folkerts H, Geugien M, van den Heuvel FA, Svendsen AF, Yi G, Martens JHA, Vellenga E. Mattes K, et al. Among authors: svendsen af. Haematologica. 2020 Aug;105(8):e399-e403. doi: 10.3324/haematol.2019.229997. Epub 2019 Nov 14. Haematologica. 2020. PMID: 31727766 Free PMC article. No abstract available.