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Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants.
Duty JA, Kraus T, Zhou H, Zhang Y, Shaabani N, Yildiz S, Du N, Singh A, Miorin L, Li D, Stegman K, Ophir S, Cao X, Atanasoff K, Lim R, Mena I, Bouvier NM, Kowdle S, Carreño JM, Rivero-Nava L, Raskin A, Moreno E, Johnson S, Rathnasinghe R, Pai CI, Kehrer T, Cabral EP, Jangra S, Healy L, Singh G, Warang P, Simon V, Sordillo EM, van Bakel H, Liu Y, Sun W, Kerwin L, Teijaro J, Schotsaert M, Krammer F, Bresson D, García-Sastre A, Fu Y, Lee B, Powers C, Moran T, Ji H, Tortorella D, Allen R. Duty JA, et al. Among authors: allen r. Med. 2022 Oct 14;3(10):705-721.e11. doi: 10.1016/j.medj.2022.08.002. Epub 2022 Aug 8. Med. 2022. PMID: 36044897 Free PMC article.
Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay.
Cao W, Cho CD, Geng ZZ, Shaabani N, Ma XR, Vatansever EC, Alugubelli YR, Ma Y, Chaki SP, Ellenburg WH, Yang KS, Qiao Y, Allen R, Neuman BW, Ji H, Xu S, Liu WR. Cao W, et al. Among authors: allen r. ACS Cent Sci. 2022 Feb 23;8(2):192-204. doi: 10.1021/acscentsci.1c00910. Epub 2022 Feb 2. ACS Cent Sci. 2022. PMID: 35229034 Free PMC article.
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Ma Y, Yang KS, Geng ZZ, Alugubelli YR, Shaabani N, Vatansever EC, Ma XR, Cho CC, Khatua K, Xiao J, Blankenship LR, Yu G, Sankaran B, Li P, Allen R, Ji H, Xu S, Liu WR. Ma Y, et al. Among authors: allen r. Eur J Med Chem. 2022 Oct 5;240:114570. doi: 10.1016/j.ejmech.2022.114570. Epub 2022 Jun 27. Eur J Med Chem. 2022. PMID: 35779291 Free PMC article.
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.
Alugubelli YR, Geng ZZ, Yang KS, Shaabani N, Khatua K, Ma XR, Vatansever EC, Cho CC, Ma Y, Xiao J, Blankenship LR, Yu G, Sankaran B, Li P, Allen R, Ji H, Xu S, Liu WR. Alugubelli YR, et al. Among authors: allen r. Eur J Med Chem. 2022 Oct 5;240:114596. doi: 10.1016/j.ejmech.2022.114596. Epub 2022 Jul 8. Eur J Med Chem. 2022. PMID: 35839690 Free PMC article.
Unbiased approach to identify and assess efficacy of human SARS-CoV-2 neutralizing antibodies.
Cao X, Maruyama J, Zhou H, Fu Y, Kerwin L, Powers C, Sattler RA, Manning JT, Singh A, Lim R, Healy LD, Johnson S, Paz Cabral E, Li D, Lu L, Ledesma A, Lee D, Richards S, Rivero-Nava L, Li Y, Shen W, Stegman K, Blair B, Urata S, Kishimoto-Urata M, Ko J, Du N, Morais K, Lawrence K, Rivera I, Pai CI, Bresson D, Brunswick M, Zhang Y, Ji H, Paessler S, Allen RD. Cao X, et al. Among authors: allen rd. Sci Rep. 2022 Sep 15;12(1):15517. doi: 10.1038/s41598-022-19780-7. Sci Rep. 2022. PMID: 36109550 Free PMC article.
Chimeric mRNA-based COVID-19 vaccine induces protective immunity against Omicron and Delta variants.
Hu Q, Zhao Y, Shaabani N, Lyu X, Powers C, Sun H, Cruz V, Stegman K, Xu J, Fossier A, Huang Y, Ho G, Kao Y, Wang Z, Wang Z, Hu Y, Zheng Y, Kyaw L, Zuluaga C, Wang H, Pei H, Allen R, Xie H, Ji H, Chen R. Hu Q, et al. Among authors: allen r. Mol Ther Nucleic Acids. 2022 Dec 13;30:465-476. doi: 10.1016/j.omtn.2022.10.021. Epub 2022 Nov 2. Mol Ther Nucleic Acids. 2022. PMID: 36345542 Free PMC article.
An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies.
Atanasoff KE, Brambilla L, Adelsberg DC, Kowdle S, Stevens CS, Hung CT, Fu Y, Lim R, Tran L, Allen R, Andrew Duty J, Bajic G, Lee B, Tortorella D. Atanasoff KE, et al. Among authors: allen r. bioRxiv [Preprint]. 2023 Apr 21:2023.04.20.537738. doi: 10.1101/2023.04.20.537738. bioRxiv. 2023. Update in: mBio. 2024 Jan 16;15(1):e0247723. doi: 10.1128/mbio.02477-23 PMID: 37131698 Free PMC article. Updated. Preprint.
A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease.
Geng ZZ, Atla S, Shaabani N, Vulupala V, Yang KS, Alugubelli YR, Khatua K, Chen PH, Xiao J, Blankenship LR, Ma XR, Vatansever EC, Cho CD, Ma Y, Allen R, Ji H, Xu S, Liu WR. Geng ZZ, et al. Among authors: allen r. J Med Chem. 2023 Aug 24;66(16):11040-11055. doi: 10.1021/acs.jmedchem.3c00221. Epub 2023 Aug 10. J Med Chem. 2023. PMID: 37561993 Free PMC article.
4,718 results