Alessi DR - Search Results

1

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Malik AU, Karapetsas A, Nirujogi RS, Chatterjee D, Phung TK, Wightman M, Gourlay R, Morrice N, Mathea S, Knapp S, Alessi DR. Malik AU, et al. Among authors: alessi dr. Biochem J. 2022 Sep 30;479(18):1941-1965. doi: 10.1042/BCJ20220308. Biochem J. 2022. PMID: 36040231 Free PMC article.

2

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.

Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P. Cross DA, et al. Among authors: alessi dr. Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):21-6. doi: 10.1042/bj3030021. Biochem J. 1994. PMID: 7945242 Free PMC article.

3

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.

James SR, Downes CP, Gigg R, Grove SJ, Holmes AB, Alessi DR. James SR, et al. Among authors: alessi dr. Biochem J. 1996 May 1;315 ( Pt 3)(Pt 3):709-13. doi: 10.1042/bj3150709. Biochem J. 1996. PMID: 8645147 Free PMC article.

4

Mechanism of activation of protein kinase B by insulin and IGF-1.

Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. Alessi DR, et al. EMBO J. 1996 Dec 2;15(23):6541-51. EMBO J. 1996. PMID: 8978681 Free PMC article.

5

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M. Alessi DR, et al. Curr Biol. 1997 Oct 1;7(10):776-89. doi: 10.1016/s0960-9822(06)00336-8. Curr Biol. 1997. PMID: 9368760 Free article.

6

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J. Alessi DR, et al. Curr Biol. 1998 Jan 15;8(2):69-81. doi: 10.1016/s0960-9822(98)70037-5. Curr Biol. 1998. PMID: 9427642 Free article.

7

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR. Walker KS, et al. Among authors: alessi dr. Biochem J. 1998 Apr 1;331 ( Pt 1)(Pt 1):299-308. doi: 10.1042/bj3310299. Biochem J. 1998. PMID: 9512493 Free PMC article.

8

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.

Shaw M, Cohen P, Alessi DR. Shaw M, et al. Among authors: alessi dr. Biochem J. 1998 Nov 15;336 ( Pt 1)(Pt 1):241-6. doi: 10.1042/bj3360241. Biochem J. 1998. PMID: 9806907 Free PMC article.

9

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J. Currie RA, et al. Among authors: alessi dr. Biochem J. 1999 Feb 1;337 ( Pt 3)(Pt 3):575-83. Biochem J. 1999. PMID: 9895304 Free PMC article.

10

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.

Casamayor A, Morrice NA, Alessi DR. Casamayor A, et al. Among authors: alessi dr. Biochem J. 1999 Sep 1;342 ( Pt 2)(Pt 2):287-92. Biochem J. 1999. PMID: 10455013 Free PMC article.

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