Sleebs BE - Search Results

1

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites.

Looker O, Dans MG, Bullen HE, Sleebs BE, Crabb BS, Gilson PR. Looker O, et al. Among authors: sleebs be. Traffic. 2022 Sep;23(9):442-461. doi: 10.1111/tra.12862. Epub 2022 Aug 15. Traffic. 2022. PMID: 36040075 Free PMC article.

2

Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.

Boddey JA, Carvalho TG, Hodder AN, Sargeant TJ, Sleebs BE, Marapana D, Lopaticki S, Nebl T, Cowman AF. Boddey JA, et al. Among authors: sleebs be. Traffic. 2013 May;14(5):532-50. doi: 10.1111/tra.12053. Epub 2013 Feb 27. Traffic. 2013. PMID: 23387285 Free article.

3

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Günther S, Whitehead LW, Lowes KN, Barfod L, Hviid L, Shaw PJ, Hodder AN, Smith BJ, Cowman AF, Boddey JA. Sleebs BE, et al. PLoS Biol. 2014 Jul 1;12(7):e1001897. doi: 10.1371/journal.pbio.1001897. eCollection 2014 Jul. PLoS Biol. 2014. PMID: 24983235 Free PMC article.

4

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, Lowes K, Smith BJ, Cowman AF, Boddey JA. Sleebs BE, et al. J Med Chem. 2014 Sep 25;57(18):7644-62. doi: 10.1021/jm500797g. Epub 2014 Sep 11. J Med Chem. 2014. PMID: 25167370

5

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG. Wilson DW, et al. Among authors: sleebs be. BMC Biol. 2015 Jul 18;13:52. doi: 10.1186/s12915-015-0162-0. BMC Biol. 2015. PMID: 26187647 Free PMC article.

6

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF. Hodder AN, et al. Among authors: sleebs be. Nat Struct Mol Biol. 2015 Aug;22(8):590-6. doi: 10.1038/nsmb.3061. Epub 2015 Jul 27. Nat Struct Mol Biol. 2015. PMID: 26214367

7

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE. Gilson PR, et al. Among authors: sleebs be. J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26. J Med Chem. 2017. PMID: 28080063

8

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J. Wong W, et al. Among authors: sleebs be. Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31. Nat Microbiol. 2017. PMID: 28288098 Free PMC article.

9

Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

Duffy S, Sykes ML, Jones AJ, Shelper TB, Simpson M, Lang R, Poulsen SA, Sleebs BE, Avery VM. Duffy S, et al. Among authors: sleebs be. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00379-17. doi: 10.1128/AAC.00379-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28674055 Free PMC article.

10

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P₂ position of PEXEL peptidomimetics.

Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE. Nguyen W, et al. Among authors: sleebs be. Eur J Med Chem. 2018 Jun 25;154:182-198. doi: 10.1016/j.ejmech.2018.05.022. Epub 2018 May 18. Eur J Med Chem. 2018. PMID: 29800827

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