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Page 1
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim CY, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R. Shin HR, et al. Among authors: laplante m. Science. 2022 Sep 16;377(6612):1290-1298. doi: 10.1126/science.abg6621. Epub 2022 Aug 25. Science. 2022. PMID: 36007018 Free PMC article.
Control of adipogenic commitment by a STAT3-VSTM2A axis.
Al Dow M, Silveira MAD, Poliquin A, Tribouillard L, Fournier É, Trébaol E, Secco B, Villot R, Tremblay F, Bilodeau S, Laplante M. Al Dow M, et al. Among authors: laplante m. Am J Physiol Endocrinol Metab. 2021 Feb 1;320(2):E259-E269. doi: 10.1152/ajpendo.00314.2020. Epub 2020 Nov 16. Am J Physiol Endocrinol Metab. 2021. PMID: 33196296 Free PMC article.
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.
de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, Pende M, Sabio G, Sabatini DM, Efeyan A. de la Calle Arregui C, et al. Among authors: laplante m. Nat Commun. 2021 Jun 16;12(1):3660. doi: 10.1038/s41467-021-23857-8. Nat Commun. 2021. PMID: 34135321 Free PMC article.
mTORC1 takes control of lysosomal lipid breakdown.
Tribouillard L, Laplante M. Tribouillard L, et al. Among authors: laplante m. Nat Metab. 2022 Dec;4(12):1620-1622. doi: 10.1038/s42255-022-00702-w. Nat Metab. 2022. PMID: 36536135 No abstract available.
HSDL2 links nutritional cues to bile acid and cholesterol homeostasis.
Samson N, Bosoi CR, Roy C, Turcotte L, Tribouillard L, Mouchiroud M, Berthiaume L, Trottier J, Silva HCG, Guerbette T, Plata-Gómez AB, Besse-Patin A, Montoni A, Ilacqua N, Lamothe J, Citron YR, Gélinas Y, Gobeil S, Zoncu R, Caron A, Morissette M, Pellegrini L, Rochette PJ, Estall JL, Efeyan A, Shum M, Audet-Walsh É, Barbier O, Marette A, Laplante M. Samson N, et al. Among authors: laplante m. Sci Adv. 2024 May 31;10(22):eadk9681. doi: 10.1126/sciadv.adk9681. Epub 2024 May 31. Sci Adv. 2024. PMID: 38820148 Free PMC article.
Connecting mTORC1 signaling to SREBP-1 activation.
Bakan I, Laplante M. Bakan I, et al. Among authors: laplante m. Curr Opin Lipidol. 2012 Jun;23(3):226-234. doi: 10.1097/MOL.0b013e328352dd03. Curr Opin Lipidol. 2012. PMID: 22449814 Review.
Loss of hepatic DEPTOR alters the metabolic transition to fasting.
Caron A, Mouchiroud M, Gautier N, Labbé SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gélinas Y, Marette A, Richard D, Sabatini DM, Laplante M. Caron A, et al. Among authors: laplante m. Mol Metab. 2017 Feb 17;6(5):447-458. doi: 10.1016/j.molmet.2017.02.005. eCollection 2017 May. Mol Metab. 2017. PMID: 28462079 Free PMC article.
163 results