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Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2.
Liu X, Kalogeropulou AF, Domingos S, Makukhin N, Nirujogi RS, Singh F, Shpiro N, Saalfrank A, Sammler E, Ganley IG, Moreira R, Alessi DR, Ciulli A. Liu X, et al. J Am Chem Soc. 2022 Sep 21;144(37):16930-16952. doi: 10.1021/jacs.2c05499. Epub 2022 Aug 25. J Am Chem Soc. 2022. PMID: 36007011 Free PMC article.
DUB be good to me.
Liu X, Ciulli A. Liu X, et al. Nat Chem Biol. 2022 Apr;18(4):358-359. doi: 10.1038/s41589-022-00978-9. Nat Chem Biol. 2022. PMID: 35210617 No abstract available.
Proximity-Based Modalities for Biology and Medicine.
Liu X, Ciulli A. Liu X, et al. ACS Cent Sci. 2023 Jul 14;9(7):1269-1284. doi: 10.1021/acscentsci.3c00395. eCollection 2023 Jul 26. ACS Cent Sci. 2023. PMID: 37521793 Free PMC article. Review.
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