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SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer.
Simmler P, Cortijo C, Koch LM, Galliker P, Angori S, Bolck HA, Mueller C, Vukolic A, Mirtschink P, Christinat Y, Davidson NR, Lehmann KV, Pellegrini G, Pauli C, Lenggenhager D, Guccini I, Ringel T, Hirt C, Marquart KF, Schaefer M, Rätsch G, Peter M, Moch H, Stoffel M, Schwank G. Simmler P, et al. Among authors: lenggenhager d. Cell Rep. 2022 Aug 23;40(8):111266. doi: 10.1016/j.celrep.2022.111266. Cell Rep. 2022. PMID: 36001976 Free article.
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: lenggenhager d. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment.
Hirt CK, Booij TH, Grob L, Simmler P, Toussaint NC, Keller D, Taube D, Ludwig V, Goryachkin A, Pauli C, Lenggenhager D, Stekhoven DJ, Stirnimann CU, Endhardt K, Ringnalda F, Villiger L, Siebenhüner A, Karkampouna S, De Menna M, Beshay J, Klett H, Kruithof-de Julio M, Schüler J, Schwank G. Hirt CK, et al. Among authors: lenggenhager d. Cell Genom. 2022 Feb;2(2):100095. doi: 10.1016/j.xgen.2022.100095. Cell Genom. 2022. PMID: 35187519 Free PMC article.
An Aggressive Hypoxia Related Subpopulation of Melanoma Cells is TRP-2 Negative.
Lenggenhager D, Curioni-Fontecedro A, Storz M, Shakhova O, Sommer L, Widmer DS, Seifert B, Moch H, Dummer R, Mihic-Probst D. Lenggenhager D, et al. Transl Oncol. 2014 Apr;7(2):206-12. doi: 10.1016/j.tranon.2014.02.018. Epub 2014 Apr 17. Transl Oncol. 2014. PMID: 24746711 Free PMC article.
Molecular and functional landscape of malignant serous effusions for precision oncology.
Wegmann R, Bankel L, Festl Y, Lau K, Lee S, Arnold F, Cappelletti V, Fehr A, Picotti P, Dedes KJ, Franzen D, Lenggenhager D, Bode PK, Zoche M, Moch H, Britschgi C, Snijder B. Wegmann R, et al. Among authors: lenggenhager d. Nat Commun. 2024 Oct 2;15(1):8544. doi: 10.1038/s41467-024-52694-8. Nat Commun. 2024. PMID: 39358333 Free PMC article.
De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer.
Steiner S, Seleznik GM, Reding T, Stopic M, Lenggenhager D, Ten Buren E, Eshmuminov D, Endhardt K, Hagedorn C, Heidenblut AM, Bratus-Neuenschwander A, Grossmann J, Trachsel C, Jabbar KS, Hahn SA, Berg JV, Graf R, Gupta A. Steiner S, et al. Among authors: lenggenhager d. Oncogene. 2022 Mar;41(10):1507-1517. doi: 10.1038/s41388-022-02182-4. Epub 2022 Jan 26. Oncogene. 2022. PMID: 35082384 Free PMC article.
45 results