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JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.
Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA. Santos CC, et al. Among authors: outeiro tf. Neurotox Res. 2022 Dec;40(6):2135-2147. doi: 10.1007/s12640-022-00559-7. Epub 2022 Aug 23. Neurotox Res. 2022. PMID: 35997936
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. Villar-Piqué A, et al. Among authors: outeiro tf. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. doi: 10.1073/pnas.1606791113. Epub 2016 Oct 5. Proc Natl Acad Sci U S A. 2016. PMID: 27708160 Free PMC article.
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.
Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM. Belo RF, et al. Among authors: outeiro tf. Front Pharmacol. 2020 Jul 9;11:985. doi: 10.3389/fphar.2020.00985. eCollection 2020. Front Pharmacol. 2020. PMID: 32733240 Free PMC article.
JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y. Fonseca-Fonseca LA, et al. Among authors: outeiro tf. Neurotoxicology. 2021 Jan;82:89-98. doi: 10.1016/j.neuro.2020.11.005. Epub 2020 Nov 21. Neurotoxicology. 2021. PMID: 33232743 Free article.
Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.
Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M. Albert K, et al. Among authors: outeiro tf. Mol Ther. 2021 Sep 1;29(9):2821-2840. doi: 10.1016/j.ymthe.2021.04.035. Epub 2021 May 1. Mol Ther. 2021. PMID: 33940158 Free PMC article.
JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats.
Wong-Guerra M, Montano-Peguero Y, Ramírez-Sánchez J, Jiménez-Martin J, Fonseca-Fonseca LA, Hernández-Enseñat D, Nonose Y, Valdés O, Mondelo-Rodriguez A, Ortiz-Miranda Y, Bergado G, Carmenate T, Soto Del Valle RM, Pardo-Andreu G, Outeiro TF, Padrón-Yaquis AS, Martimbianco de Assis A, O Souza D, Nuñez-Figueredo Y. Wong-Guerra M, et al. Among authors: outeiro tf. Neurotoxicology. 2021 Dec;87:70-85. doi: 10.1016/j.neuro.2021.08.017. Epub 2021 Sep 2. Neurotoxicology. 2021. PMID: 34481871
Extracellular alpha-synuclein: Sensors, receptors, and responses.
Domingues R, Sant'Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TF. Domingues R, et al. Among authors: outeiro tf. Neurobiol Dis. 2022 Jun 15;168:105696. doi: 10.1016/j.nbd.2022.105696. Epub 2022 Mar 20. Neurobiol Dis. 2022. PMID: 35321855 Free article. Review.
Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes.
Chegão A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H. Chegão A, et al. Among authors: outeiro tf. NPJ Parkinsons Dis. 2022 Apr 25;8(1):51. doi: 10.1038/s41531-022-00314-x. NPJ Parkinsons Dis. 2022. PMID: 35468899 Free PMC article.
A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity.
Queiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD. Queiroz DD, et al. Among authors: outeiro tf. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166475. doi: 10.1016/j.bbadis.2022.166475. Epub 2022 Jun 28. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35777688 Free article.
352 results