Foguel D - Search Results

1

JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.

Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA. Santos CC, et al. Among authors: foguel d. Neurotox Res. 2022 Dec;40(6):2135-2147. doi: 10.1007/s12640-022-00559-7. Epub 2022 Aug 23. Neurotox Res. 2022. PMID: 35997936

2

Peripheral nervous system is injured by neutrophil extracellular traps (NETs) elicited by nonstructural (NS) protein-1 from Zika virus.

de Siqueira Santos R, Rochael NC, Mattos TRF, Fallett E Silva MF, Linhares-Lacerda L, de Oliveira LT, Cunha MS, Mohana-Borges R, Gomes TA, Barbosa-Silva MC, Maron-Gutierrez T, Foguel D, Saraiva EM. de Siqueira Santos R, et al. Among authors: foguel d. FASEB J. 2023 Sep;37(9):e23126. doi: 10.1096/fj.202201904R. FASEB J. 2023. PMID: 37594040

3

Trapping the monomer of a non-amyloidogenic variant of transthyretin: exploring its possible use as a therapeutic strategy against transthyretin amyloidogenic diseases.

Palhano FL, Leme LP, Busnardo RG, Foguel D. Palhano FL, et al. Among authors: foguel d. J Biol Chem. 2009 Jan 16;284(3):1443-53. doi: 10.1074/jbc.M807100200. Epub 2008 Nov 4. J Biol Chem. 2009. PMID: 18984591 Free article.

4

A fluorescent mutant of the NM domain of the yeast prion Sup35 provides insight into fibril formation and stability.

Palhano FL, Rocha CB, Bernardino A, Weissmuller G, Masuda CA, Montero-Lomelí M, Gomes AM, Chien P, Fernandes PM, Foguel D. Palhano FL, et al. Among authors: foguel d. Biochemistry. 2009 Jul 28;48(29):6811-23. doi: 10.1021/bi9000276. Biochemistry. 2009. PMID: 19530740

5

Identification of archaeal proteins that affect the exosome function in vitro.

Luz JS, Ramos CR, Santos MC, Coltri PP, Palhano FL, Foguel D, Zanchin NI, Oliveira CC. Luz JS, et al. Among authors: foguel d. BMC Biochem. 2010 May 27;11:22. doi: 10.1186/1471-2091-11-22. BMC Biochem. 2010. PMID: 20507607 Free PMC article.

6

The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species.

Braga CA, Follmer C, Palhano FL, Khattar E, Freitas MS, Romão L, Di Giovanni S, Lashuel HA, Silva JL, Foguel D. Braga CA, et al. Among authors: foguel d. J Mol Biol. 2011 Jan 7;405(1):254-73. doi: 10.1016/j.jmb.2010.10.027. Epub 2010 Nov 2. J Mol Biol. 2011. PMID: 21050861

7

Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid.

Azevedo EP, Pereira HM, Garratt RC, Kelly JW, Foguel D, Palhano FL. Azevedo EP, et al. Among authors: foguel d. Biochemistry. 2011 Dec 27;50(51):11070-83. doi: 10.1021/bi201365r. Epub 2011 Nov 30. Biochemistry. 2011. PMID: 22091638

8

Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase.

Azevedo EP, Guimarães-Costa AB, Torezani GS, Braga CA, Palhano FL, Kelly JW, Saraiva EM, Foguel D. Azevedo EP, et al. Among authors: foguel d. J Biol Chem. 2012 Oct 26;287(44):37206-18. doi: 10.1074/jbc.M112.369942. Epub 2012 Aug 23. J Biol Chem. 2012. PMID: 22918834 Free PMC article.

9

Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis.

Azevedo EP, Ledo JH, Barbosa G, Sobrinho M, Diniz L, Fonseca AC, Gomes F, Romão L, Lima FR, Palhano FL, Ferreira ST, Foguel D. Azevedo EP, et al. Among authors: foguel d. Cell Death Dis. 2013 Sep 5;4(9):e789. doi: 10.1038/cddis.2013.325. Cell Death Dis. 2013. PMID: 24008733 Free PMC article.

10

Conformational changes in human Hsp70 induced by high hydrostatic pressure produce oligomers with ATPase activity but without chaperone activity.

Araujo TL, Borges JC, Ramos CH, Meyer-Fernandes JR, Oliveira Júnior RS, Pascutti PG, Foguel D, Palhano FL. Araujo TL, et al. Among authors: foguel d. Biochemistry. 2014 May 13;53(18):2884-9. doi: 10.1021/bi500004q. Epub 2014 Apr 29. Biochemistry. 2014. PMID: 24739062

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