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Celastrol: A lead compound that inhibits SARS-CoV-2 replication, the activity of viral and human cysteine proteases, and virus-induced IL-6 secretion.
Fuzo CA, Martins RB, Fraga-Silva TFC, Amstalden MK, Canassa De Leo T, Souza JP, Lima TM, Faccioli LH, Okamoto DN, Juliano MA, França SC, Juliano L, Bonato VLD, Arruda E, Dias-Baruffi M. Fuzo CA, et al. Among authors: arruda e. Drug Dev Res. 2022 Nov;83(7):1623-1640. doi: 10.1002/ddr.21982. Epub 2022 Aug 21. Drug Dev Res. 2022. PMID: 35989498 Free PMC article.
Oropouche virus is detected in peripheral blood leukocytes from patients.
de Souza Luna LK, Rodrigues AH, Santos RI, Sesti-Costa R, Criado MF, Martins RB, Silva ML, Delcaro LS, Proença-Modena JL, Figueiredo LT, Acrani GO, Arruda E. de Souza Luna LK, et al. Among authors: arruda e. J Med Virol. 2017 Jun;89(6):1108-1111. doi: 10.1002/jmv.24722. Epub 2017 Feb 24. J Med Virol. 2017. PMID: 27787907
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Veras FP, Pontelli MC, Silva CM, Toller-Kawahisa JE, de Lima M, Nascimento DC, Schneider AH, Caetité D, Tavares LA, Paiva IM, Rosales R, Colón D, Martins R, Castro IA, Almeida GM, Lopes MIF, Benatti MN, Bonjorno LP, Giannini MC, Luppino-Assad R, Almeida SL, Vilar F, Santana R, Bollela VR, Auxiliadora-Martins M, Borges M, Miranda CH, Pazin-Filho A, da Silva LLP, Cunha LD, Zamboni DS, Dal-Pizzol F, Leiria LO, Siyuan L, Batah S, Fabro A, Mauad T, Dolhnikoff M, Duarte-Neto A, Saldiva P, Cunha TM, Alves-Filho JC, Arruda E, Louzada-Junior P, Oliveira RD, Cunha FQ. Veras FP, et al. Among authors: arruda e. J Exp Med. 2020 Dec 7;217(12):e20201129. doi: 10.1084/jem.20201129. J Exp Med. 2020. PMID: 32926098 Free PMC article.
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Rodrigues TS, et al. Among authors: arruda e. J Exp Med. 2021 Mar 1;218(3):e20201707. doi: 10.1084/jem.20201707. J Exp Med. 2021. PMID: 33231615 Free PMC article.
Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients.
Potje SR, Costa TJ, Fraga-Silva TFC, Martins RB, Benatti MN, Almado CEL, de Sá KSG, Bonato VLD, Arruda E, Louzada-Junior P, Oliveira RDR, Zamboni DS, Becari C, Auxiliadora-Martins M, Tostes RC. Potje SR, et al. Among authors: arruda e. Life Sci. 2021 Jul 1;276:119376. doi: 10.1016/j.lfs.2021.119376. Epub 2021 Mar 27. Life Sci. 2021. PMID: 33781826 Free PMC article.
The use of denaturing solution as collection and transport media to improve SARS-CoV-2 RNA detection and reduce infection of laboratory personnel.
Carvalho AF, Rocha RP, Gonçalves AP, Silva TBS, Sato HI, Vuitika L, Bagno FF, Sérgio SAR, Figueiredo MM, Martins RB, Souza JP, Arruda E, Fernandes APSM, Alves PA, Teixeira SMR, da Fonseca FG. Carvalho AF, et al. Among authors: arruda e. Braz J Microbiol. 2021 Jun;52(2):531-539. doi: 10.1007/s42770-021-00469-4. Epub 2021 Mar 31. Braz J Microbiol. 2021. PMID: 33788178 Free PMC article.
Detection of respiratory viruses in primary cholesteatoma tissues.
Viana RMM, Souza JP, Jorge DMM, Martins RB, Castro IA, Cardoso RS, Volpini LPB, de Souza Luna LK, Spano LC, Bellei NCJ, Chahud F, Arruda E, A Hyppolito M. Viana RMM, et al. Among authors: arruda e. J Med Virol. 2021 Nov;93(11):6132-6139. doi: 10.1002/jmv.27107. Epub 2021 Jun 10. J Med Virol. 2021. PMID: 34050944
Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage.
Costa TJ, Potje SR, Fraga-Silva TFC, da Silva-Neto JA, Barros PR, Rodrigues D, Machado MR, Martins RB, Santos-Eichler RA, Benatti MN, de Sá KSG, Almado CEL, Castro ÍA, Pontelli MC, Serra L, Carneiro FS, Becari C, Louzada-Junior P, Oliveira RDR, Zamboni DS, Arruda E, Auxiliadora-Martins M, Giachini FRC, Bonato VLD, Zachara NE, Bomfim GF, Tostes RC. Costa TJ, et al. Among authors: arruda e. Vascul Pharmacol. 2022 Feb;142:106946. doi: 10.1016/j.vph.2021.106946. Epub 2021 Nov 25. Vascul Pharmacol. 2022. PMID: 34838735 Free PMC article.
Neural Infection by Oropouche Virus in Adult Human Brain Slices Induces an Inflammatory and Toxic Response.
Almeida GM, Souza JP, Mendes ND, Pontelli MC, Pinheiro NR, Nogueira GO, Cardoso RS, Paiva IM, Ferrari GD, Veras FP, Cunha FQ, Horta-Junior JAC, Alberici LC, Cunha TM, Podolsky-Gondim GG, Neder L, Arruda E, Sebollela A. Almeida GM, et al. Among authors: arruda e. Front Neurosci. 2021 Nov 23;15:674576. doi: 10.3389/fnins.2021.674576. eCollection 2021. Front Neurosci. 2021. PMID: 34887719 Free PMC article.
337 results