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Page 1
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.
Pal S, Kaplan JP, Nguyen H, Stopka SA, Savani MR, Regan MS, Nguyen QD, Jones KL, Moreau LA, Peng J, Dipiazza MG, Perciaccante AJ, Zhu X, Hunsel BR, Liu KX, Alexandrescu S, Drissi R, Filbin MG, McBrayer SK, Agar NYR, Chowdhury D, Haas-Kogan DA. Pal S, et al. Among authors: perciaccante aj. Cancer Cell. 2022 Sep 12;40(9):957-972.e10. doi: 10.1016/j.ccell.2022.07.012. Epub 2022 Aug 18. Cancer Cell. 2022. PMID: 35985342 Free PMC article.
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Sebastian C, Ferrer C, Serra M, Choi JE, Ducano N, Mira A, Shah MS, Stopka SA, Perciaccante AJ, Isella C, Moya-Rull D, Vara-Messler M, Giordano S, Maldi E, Desai N, Capen DE, Medico E, Cetinbas M, Sadreyev RI, Brown D, Rivera MN, Sapino A, Breault DT, Agar NYR, Mostoslavsky R. Sebastian C, et al. Among authors: perciaccante aj. Nat Commun. 2022 Mar 21;13(1):1503. doi: 10.1038/s41467-022-29085-y. Nat Commun. 2022. PMID: 35314684 Free PMC article.
Covalent Modification of p53 by (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one.
Brown K, Robello M, Perciaccante AJ, Dinan JC, Maity TK, Lyons GC, Kumar JP, Durell SR, Tagad HD, Schilling D, Nikolayevskiy H, O'Connor R, Appella E, Appella DH, Jenkins LM. Brown K, et al. Among authors: perciaccante aj. ACS Pharmacol Transl Sci. 2024 Oct 14;7(11):3559-3572. doi: 10.1021/acsptsci.4c00447. eCollection 2024 Nov 8. ACS Pharmacol Transl Sci. 2024. PMID: 39539265
The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species.
González Dalmasy JM, Fitzsimmons CM, Frye WJE, Perciaccante AJ, Jewell CP, Jenkins LM, Batista PJ, Robey RW, Gottesman MM. González Dalmasy JM, et al. Among authors: perciaccante aj. Chem Biol Interact. 2024 May 1;394:110989. doi: 10.1016/j.cbi.2024.110989. Epub 2024 Apr 3. Chem Biol Interact. 2024. PMID: 38574836
The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors.
Robey RW, Fitzsimmons CM, Guiblet WM, Frye WJE, González Dalmasy JM, Wang L, Russell DA, Huff LM, Perciaccante AJ, Ali-Rahmani F, Lipsey CC, Wade HM, Mitchell AV, Maligireddy SS, Terrero D, Butcher D, Edmondson EF, Jenkins LM, Nikitina T, Zhurkin VB, Tiwari AK, Piscopio AD, Totah RA, Bates SE, Arda HE, Gottesman MM, Batista PJ. Robey RW, et al. Among authors: perciaccante aj. Mol Cancer Ther. 2024 Apr 2;23(4):464-477. doi: 10.1158/1535-7163.MCT-23-0144. Mol Cancer Ther. 2024. PMID: 38151817 Free PMC article.
The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species.
González Dalmasy JM, Fitzsimmons CM, Frye WJE, Perciaccante AJ, Jewell CP, Jenkins LM, Batista PJ, Robey RW, Gottesman MM. González Dalmasy JM, et al. Among authors: perciaccante aj. bioRxiv [Preprint]. 2023 Nov 17:2023.11.17.567538. doi: 10.1101/2023.11.17.567538. bioRxiv. 2023. Update in: Chem Biol Interact. 2024 May 1;394:110989. doi: 10.1016/j.cbi.2024.110989 PMID: 38076968 Free PMC article. Updated. Preprint.