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A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations.
Ou J, Lewandowski EM, Hu Y, Lipinski AA, Morgan RT, Jacobs LMC, Zhang X, Bikowitz MJ, Langlais P, Tan H, Wang J, Chen Y, Choy JS. Ou J, et al. Among authors: chen y. bioRxiv [Preprint]. 2022 Aug 8:2022.08.06.503039. doi: 10.1101/2022.08.06.503039. bioRxiv. 2022. Update in: PLoS Pathog. 2023 Aug 31;19(8):e1011592. doi: 10.1371/journal.ppat.1011592 PMID: 35982672 Free PMC article. Updated. Preprint.
Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir.
Hu Y, Lewandowski EM, Tan H, Zhang X, Morgan RT, Zhang X, Jacobs LMC, Butler SG, Gongora MV, Choy J, Deng X, Chen Y, Wang J. Hu Y, et al. Among authors: chen y. bioRxiv [Preprint]. 2022 Sep 6:2022.06.28.497978. doi: 10.1101/2022.06.28.497978. bioRxiv. 2022. Update in: ACS Cent Sci. 2023 Jul 24;9(8):1658-1669. doi: 10.1021/acscentsci.3c00538 PMID: 36119652 Free PMC article. Updated. Preprint.
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