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Page 1
Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy.
Fox SN, McMeekin LJ, Savage CH, Joyce KL, Boas SM, Simmons MS, Farmer CB, Ryan J, Pereboeva L, Becker K, Auwerx J, Sudarshan S, Ma J, Lee A, Roberts RC, Crossman DK, Kralli A, Cowell RM. Fox SN, et al. Among authors: auwerx j. NPJ Parkinsons Dis. 2022 Aug 18;8(1):106. doi: 10.1038/s41531-022-00369-w. NPJ Parkinsons Dis. 2022. PMID: 35982091 Free PMC article.
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression.
Benegiamo G, von Alvensleben GVG, Rodríguez-López S, Goeminne LJE, Bachmann AM, Morel JD, Broeckx E, Ma JY, Carreira V, Youssef SA, Azhar N, Reilly DF, D'Aquino K, Mullican S, Bou-Sleiman M, Auwerx J. Benegiamo G, et al. Among authors: auwerx j. J Exp Med. 2023 Apr 3;220(4):e20221738. doi: 10.1084/jem.20221738. Epub 2023 Feb 14. J Exp Med. 2023. PMID: 36787127 Free PMC article.
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.
Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP. Gan Z, et al. Among authors: auwerx j. J Clin Invest. 2013 Jun;123(6):2564-75. doi: 10.1172/JCI67652. Epub 2013 May 8. J Clin Invest. 2013. PMID: 23676496 Free PMC article.
Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
Chanda D, Thoudam T, Sinam IS, Lim CW, Kim M, Wang J, Lee KM, Ma J, Saxena R, Choi J, Oh CJ, Lee H, Jeon YH, Cho SJ, Jung HY, Park KG, Choi HS, Suh JM, Auwerx J, Ji B, Liangpunsakul S, Jeon JH, Lee IK. Chanda D, et al. Among authors: auwerx j. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2219644120. doi: 10.1073/pnas.2219644120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155882 Free PMC article.
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Among authors: auwerx j. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.
Pharmacological approaches to restore mitochondrial function.
Andreux PA, Houtkooper RH, Auwerx J. Andreux PA, et al. Among authors: auwerx j. Nat Rev Drug Discov. 2013 Jun;12(6):465-83. doi: 10.1038/nrd4023. Epub 2013 May 13. Nat Rev Drug Discov. 2013. PMID: 23666487 Free PMC article. Review.
NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.
Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. Ryu D, et al. Among authors: auwerx j. Sci Transl Med. 2016 Oct 19;8(361):361ra139. doi: 10.1126/scitranslmed.aaf5504. Sci Transl Med. 2016. PMID: 27798264 Free PMC article.
635 results