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A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant Neisseria gonorrhoeae and Other High-Threat Pathogens.
Park S, Russo R, Westfall L, Shrestha R, Zimmerman M, Dartois V, Kurepina N, Kreiswirth B, Singleton E, Li SG, Mittal N, Ahn YM, Bilotta J, Connolly KL, Jerse AE, Freundlich JS, Perlin DS. Park S, et al. Among authors: freundlich js. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0041422. doi: 10.1128/aac.00414-22. Epub 2022 Aug 16. Antimicrob Agents Chemother. 2022. PMID: 35972242 Free PMC article.
Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures.
Jain S, Chen X, Arun B, Meza ON, Sarhan M, Singh M, Jeon B, Mane K, Shah M, Tucker E, Carroll L, Freundlich J, Peloquin C, Ivaturi V. Jain S, et al. Res Sq [Preprint]. 2024 Mar 21:rs.3.rs-4096014. doi: 10.21203/rs.3.rs-4096014/v1. Res Sq. 2024. Update in: Nat Commun. 2024 Aug 14;15(1):6657. doi: 10.1038/s41467-024-50989-4. PMID: 38562706 Free PMC article. Updated. Preprint.
Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.
Ekins S, Madrid PB, Sarker M, Li SG, Mittal N, Kumar P, Wang X, Stratton TP, Zimmerman M, Talcott C, Bourbon P, Travers M, Yadav M, Freundlich JS. Ekins S, et al. Among authors: freundlich js. PLoS One. 2015 Oct 30;10(10):e0141076. doi: 10.1371/journal.pone.0141076. eCollection 2015. PLoS One. 2015. PMID: 26517557 Free PMC article.
Discovery of MRSA active antibiotics using primary sequence from the human microbiome.
Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen LJ, Gordon EA, Reddy BV, Charlop-Powers Z, Zebroski HA, Gallardo-Macias R, Jaskowski M, Satish S, Park S, Perlin DS, Freundlich JS, Brady SF. Chu J, et al. Among authors: freundlich js. Nat Chem Biol. 2016 Dec;12(12):1004-1006. doi: 10.1038/nchembio.2207. Epub 2016 Oct 17. Nat Chem Biol. 2016. PMID: 27748750 Free PMC article.
Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.
Vila-Farres X, Chu J, Inoyama D, Ternei MA, Lemetre C, Cohen LJ, Cho W, Reddy BV, Zebroski HA, Freundlich JS, Perlin DS, Brady SF. Vila-Farres X, et al. Among authors: freundlich js. J Am Chem Soc. 2017 Feb 1;139(4):1404-1407. doi: 10.1021/jacs.6b11861. Epub 2017 Jan 23. J Am Chem Soc. 2017. PMID: 28055186 Free PMC article.
A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells.
Sukheja P, Kumar P, Mittal N, Li SG, Singleton E, Russo R, Perryman AL, Shrestha R, Awasthi D, Husain S, Soteropoulos P, Brukh R, Connell N, Freundlich JS, Alland D. Sukheja P, et al. Among authors: freundlich js. mBio. 2017 Feb 14;8(1):e02022-16. doi: 10.1128/mBio.02022-16. mBio. 2017. PMID: 28196957 Free PMC article.
Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins.
Kumar P, Chauhan V, Silva JRA, Lameira J, d'Andrea FB, Li SG, Ginell SL, Freundlich JS, Alves CN, Bailey S, Cohen KA, Lamichhane G. Kumar P, et al. Among authors: freundlich js. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00866-17. doi: 10.1128/AAC.00866-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28760902 Free PMC article.
94 results