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Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy.
Boddupalli CS, Nair S, Belinsky G, Gans J, Teeple E, Nguyen TH, Mehta S, Guo L, Kramer ML, Ruan J, Wang H, Davison M, Kumar D, Vidyadhara DJ, Zhang B, Klinger K, Mistry PK. Boddupalli CS, et al. Among authors: guo l. Elife. 2022 Aug 16;11:e79830. doi: 10.7554/eLife.79830. Elife. 2022. PMID: 35972072 Free PMC article.
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis.
Zelic M, Pontarelli F, Woodworth L, Zhu C, Mahan A, Ren Y, LaMorte M, Gruber R, Keane A, Loring P, Guo L, Xia TH, Zhang B, Orning P, Lien E, Degterev A, Hammond T, Ofengeim D. Zelic M, et al. Among authors: guo l. Cell Rep. 2021 May 11;35(6):109112. doi: 10.1016/j.celrep.2021.109112. Cell Rep. 2021. PMID: 33979622 Free PMC article.
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration.
Ryan SK, Zelic M, Han Y, Teeple E, Chen L, Sadeghi M, Shankara S, Guo L, Li C, Pontarelli F, Jensen EH, Comer AL, Kumar D, Zhang M, Gans J, Zhang B, Proto JD, Saleh J, Dodge JC, Savova V, Rajpal D, Ofengeim D, Hammond TR. Ryan SK, et al. Among authors: guo l. Nat Neurosci. 2023 Jan;26(1):12-26. doi: 10.1038/s41593-022-01221-3. Epub 2022 Dec 19. Nat Neurosci. 2023. PMID: 36536241 Free PMC article.
Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro.
Cheong A, Craciun F, Husson H, Gans J, Escobedo J, Chang YC, Guo L, Goncalves M, Kaplan N, Smith LA, Moreno S, Boulanger J, Liu S, Saleh J, Zhang M, Blazier AS, Qiu W, Macklin A, Iyyanki T, Chatelain C, Khader S, Natoli TA, Ibraghimov-Beskrovnaya O, Ofengeim D, Proto JD. Cheong A, et al. Among authors: guo l. Commun Biol. 2024 Aug 2;7(1):932. doi: 10.1038/s42003-024-06606-7. Commun Biol. 2024. PMID: 39095617 Free PMC article.
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