Eck MJ - Search Results

1

PH domain-mediated autoinhibition and oncogenic activation of Akt.

Bae H, Viennet T, Park E, Chu N, Salguero A, Eck MJ, Arthanari H, Cole PA. Bae H, et al. Among authors: eck mj. Elife. 2022 Aug 15;11:e80148. doi: 10.7554/eLife.80148. Elife. 2022. PMID: 35968932 Free PMC article.

2

Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism.

Sondhi D, Xu W, Songyang Z, Eck MJ, Cole PA. Sondhi D, et al. Among authors: eck mj. Biochemistry. 1998 Jan 6;37(1):165-72. doi: 10.1021/bi9722960. Biochemistry. 1998. PMID: 9425036

3

Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6.

Tu D, Graziano BR, Park E, Zheng W, Li Y, Goode BL, Eck MJ. Tu D, et al. Among authors: eck mj. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3424-33. doi: 10.1073/pnas.1203035109. Epub 2012 Nov 16. Proc Natl Acad Sci U S A. 2012. PMID: 23161908 Free PMC article.

4

PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.

Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. Hu Y, et al. Among authors: eck mj. Cancer Discov. 2014 Dec;4(12):1430-47. doi: 10.1158/2159-8290.CD-13-0891. Epub 2014 Sep 24. Cancer Discov. 2014. PMID: 25252691 Free PMC article.

5

Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.

Park E, Graziano BR, Zheng W, Garabedian M, Goode BL, Eck MJ. Park E, et al. Among authors: eck mj. Structure. 2015 Aug 4;23(8):1492-1499. doi: 10.1016/j.str.2015.05.015. Epub 2015 Jun 25. Structure. 2015. PMID: 26118535 Free PMC article.

6

Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.

Park E, Kim N, Ficarro SB, Zhang Y, Lee BI, Cho A, Kim K, Park AKJ, Park WY, Murray B, Meyerson M, Beroukhim R, Marto JA, Cho J, Eck MJ. Park E, et al. Among authors: eck mj. Nat Struct Mol Biol. 2015 Sep;22(9):703-711. doi: 10.1038/nsmb.3074. Epub 2015 Aug 17. Nat Struct Mol Biol. 2015. PMID: 26280531 Free PMC article.

7

SPLINTS: small-molecule protein ligand interface stabilizers.

Fischer ES, Park E, Eck MJ, Thomä NH. Fischer ES, et al. Among authors: eck mj. Curr Opin Struct Biol. 2016 Apr;37:115-22. doi: 10.1016/j.sbi.2016.01.004. Epub 2016 Jan 30. Curr Opin Struct Biol. 2016. PMID: 26829757 Free PMC article. Review.

8

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.

Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H, Palakurthi S, Jang J, Lelais G, DiDonato M, Bursulaya B, Michellys PY, Epple R, Marsilje TH, McNeill M, Lu W, Harris J, Bender S, Wong KK, Jänne PA, Eck MJ. Jia Y, et al. Among authors: eck mj. Nature. 2016 Jun 2;534(7605):129-32. doi: 10.1038/nature17960. Epub 2016 May 25. Nature. 2016. PMID: 27251290 Free PMC article.

9

Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes.

Ficarro SB, Browne CM, Card JD, Alexander WM, Zhang T, Park E, McNally R, Dhe-Paganon S, Seo HS, Lamberto I, Eck MJ, Buhrlage SJ, Gray NS, Marto JA. Ficarro SB, et al. Among authors: eck mj. Anal Chem. 2016 Dec 20;88(24):12248-12254. doi: 10.1021/acs.analchem.6b03394. Epub 2016 Nov 30. Anal Chem. 2016. PMID: 28193034

10

Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.

Jang J, Son J, Park E, Kosaka T, Saxon JA, De Clercq DJH, Choi HG, Tanizaki J, Eck MJ, Jänne PA, Gray NS. Jang J, et al. Among authors: eck mj. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11629-11633. doi: 10.1002/anie.201805187. Epub 2018 Aug 3. Angew Chem Int Ed Engl. 2018. PMID: 29978938 Free PMC article.

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