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Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy.
Ali A, Nykanen AI, Beroncal E, Brambate E, Mariscal A, Michaelsen V, Wang A, Kawashima M, Ribeiro RVP, Zhang Y, Fan E, Brochard L, Yeung J, Waddell T, Liu M, Andreazza AC, Keshavjee S, Cypel M. Ali A, et al. Among authors: wang a. EBioMedicine. 2022 Sep;83:104210. doi: 10.1016/j.ebiom.2022.104210. Epub 2022 Aug 8. EBioMedicine. 2022. PMID: 35952495 Free PMC article.
Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function.
Ali A, Wang A, Ribeiro RVP, Beroncal EL, Baciu C, Galasso M, Gomes B, Mariscal A, Hough O, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Gazzalle A, Fan E, Brochard L, Yeung J, Waddell T, Liu M, Andreazza AC, Keshavjee S, Cypel M. Ali A, et al. Among authors: wang a. Sci Transl Med. 2021 Sep 15;13(611):eabf7601. doi: 10.1126/scitranslmed.abf7601. Epub 2021 Sep 15. Sci Transl Med. 2021. PMID: 34524862
A novel pre-clinical strategy to deliver antimicrobial doses of inhaled nitric oxide.
Michaelsen VS, Ribeiro RVP, Brambate E, Ali A, Wang A, Pires L, Kawashima M, Zhang Y, Gazzalle A, Keshavjee S, Del Sorbo L, Cypel M. Michaelsen VS, et al. Among authors: wang a. PLoS One. 2021 Oct 13;16(10):e0258368. doi: 10.1371/journal.pone.0258368. eCollection 2021. PLoS One. 2021. PMID: 34644318 Free PMC article.
Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin.
Ribeiro RVP, Ku T, Wang A, Pires L, Ferreira VH, Michaelsen V, Ali A, Galasso M, Moshkelgosha S, Gazzalle A, Jeppesen MG, Rosenkilde MM, Liu M, Singer LG, Kumar D, Keshavjee S, Sinclair J, Kledal TN, Humar A, Cypel M. Ribeiro RVP, et al. Among authors: wang a. J Heart Lung Transplant. 2022 Mar;41(3):287-297. doi: 10.1016/j.healun.2021.10.010. Epub 2021 Oct 25. J Heart Lung Transplant. 2022. PMID: 34802874
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs.
Wang A, Ribeiro RVP, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell TK, Cserti-Gazdewich C, Tinckam K, Kizhakkedathu JN, West L, Keshavjee S, Withers SG, Cypel M. Wang A, et al. Sci Transl Med. 2022 Feb 16;14(632):eabm7190. doi: 10.1126/scitranslmed.abm7190. Epub 2022 Feb 16. Sci Transl Med. 2022. PMID: 35171649
The metabolic fate of oxaliplatin in the biological milieu investigated during in vivo lung perfusion using a unique miniaturized sampling approach based on solid-phase microextraction coupled with liquid chromatography-mass spectrometry.
Olkowicz M, Rosales-Solano H, Ramadan K, Wang A, Cypel M, Pawliszyn J. Olkowicz M, et al. Among authors: wang a. Front Cell Dev Biol. 2022 Aug 25;10:928152. doi: 10.3389/fcell.2022.928152. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36092704 Free PMC article.
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