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Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma.
Torrini C, Nguyen TTT, Shu C, Mela A, Humala N, Mahajan A, Seeley EH, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Torrini C, et al. Among authors: karpel massler g. Mol Cell. 2022 Aug 18;82(16):3061-3076.e6. doi: 10.1016/j.molcel.2022.06.030. Epub 2022 Aug 9. Mol Cell. 2022. PMID: 35948010 Free PMC article.
Erlotinib in glioblastoma: lost in translation?
Karpel-Massler G, Westhoff MA, Kast RE, Wirtz CR, Halatsch ME. Karpel-Massler G, et al. Anticancer Agents Med Chem. 2011 Oct;11(8):748-55. doi: 10.2174/187152011797378788. Anticancer Agents Med Chem. 2011. PMID: 21707495 Review.
Inhibition of NF-κB signaling ablates the invasive phenotype of glioblastoma.
Westhoff MA, Zhou S, Nonnenmacher L, Karpel-Massler G, Jennewein C, Schneider M, Halatsch ME, Carragher NO, Baumann B, Krause A, Simmet T, Bachem MG, Wirtz CR, Debatin KM. Westhoff MA, et al. Mol Cancer Res. 2013 Dec;11(12):1611-23. doi: 10.1158/1541-7786.MCR-13-0435-T. Epub 2013 Oct 21. Mol Cancer Res. 2013. PMID: 24145173
Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy.
Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P. Lewerenz J, et al. Antioxid Redox Signal. 2014 Jun 20;20(18):2907-22. doi: 10.1089/ars.2013.5455. Epub 2014 Feb 6. Antioxid Redox Signal. 2014. PMID: 24219064 Free PMC article.
Killing me softly--future challenges in apoptosis research.
Westhoff MA, Brühl O, Nonnenmacher L, Karpel-Massler G, Debatin KM. Westhoff MA, et al. Int J Mol Sci. 2014 Mar 3;15(3):3746-67. doi: 10.3390/ijms15033746. Int J Mol Sci. 2014. PMID: 24595238 Free PMC article. Review.
RIST: a potent new combination therapy for glioblastoma.
Nonnenmacher L, Westhoff MA, Fulda S, Karpel-Massler G, Halatsch ME, Engelke J, Simmet T, Corbacioglu S, Debatin KM. Nonnenmacher L, et al. Int J Cancer. 2015 Feb 15;136(4):E173-87. doi: 10.1002/ijc.29138. Epub 2014 Sep 1. Int J Cancer. 2015. PMID: 25123598
PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.
Karpel-Massler G, Pareja F, Aimé P, Shu C, Chau L, Westhoff MA, Halatsch ME, Crary JF, Canoll P, Siegelin MD. Karpel-Massler G, et al. PLoS One. 2014 Dec 22;9(12):e114583. doi: 10.1371/journal.pone.0114583. eCollection 2014. PLoS One. 2014. PMID: 25531448 Free PMC article.
105 results