Okanishi H - Search Results

1

Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10.

Ohtsu N, Ohgaki R, Jin C, Xu M, Okanishi H, Takahashi R, Matsui A, Kishimoto W, Ishiguro N, Kanai Y. Ohtsu N, et al. Among authors: okanishi h. J Pharmacol Sci. 2022 Sep;150(1):41-48. doi: 10.1016/j.jphs.2022.06.003. Epub 2022 Jun 17. J Pharmacol Sci. 2022. PMID: 35926947 Free article.

2

Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes.

Jin C, Wei L, Ohgaki R, Tominaga H, Xu M, Okuda S, Okanishi H, Kawamoto Y, He X, Nagamori S, Kanai Y. Jin C, et al. Among authors: okanishi h. J Pharmacol Exp Ther. 2020 Dec;375(3):451-462. doi: 10.1124/jpet.120.000235. Epub 2020 Sep 27. J Pharmacol Exp Ther. 2020. PMID: 32981893

3

Structural changes induced by ligand binding drastically increase the thermostability of the Ser/Thr protein kinase TpkD from Thermus thermophilus HB8.

Fujino Y, Miyagawa T, Torii M, Inoue M, Fujii Y, Okanishi H, Kanai Y, Masui R. Fujino Y, et al. Among authors: okanishi h. FEBS Lett. 2021 Jan;595(2):264-274. doi: 10.1002/1873-3468.13996. Epub 2020 Nov 28. FEBS Lett. 2021. PMID: 33159808 Free article.

4

Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation.

Quan L, Ohgaki R, Hara S, Okuda S, Wei L, Okanishi H, Nagamori S, Endou H, Kanai Y. Quan L, et al. Among authors: okanishi h. J Exp Clin Cancer Res. 2020 Nov 30;39(1):266. doi: 10.1186/s13046-020-01762-0. J Exp Clin Cancer Res. 2020. PMID: 33256804 Free PMC article.

5

Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor.

Okanishi H, Ohgaki R, Okuda S, Endou H, Kanai Y. Okanishi H, et al. Cancer Sci. 2021 Feb;112(2):871-883. doi: 10.1111/cas.14756. Epub 2020 Dec 19. Cancer Sci. 2021. PMID: 33264461 Free PMC article.

6

Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells.

Nishikubo K, Ohgaki R, Okanishi H, Okuda S, Xu M, Endou H, Kanai Y. Nishikubo K, et al. Among authors: okanishi h. J Cell Mol Med. 2022 Oct;26(20):5246-5256. doi: 10.1111/jcmm.17553. Epub 2022 Sep 7. J Cell Mol Med. 2022. PMID: 36071551 Free PMC article.

7

Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8.

Nakatani M, Nakahara SY, Fukui K, Urano M, Fujii Y, Murakawa T, Baba S, Kumasaka T, Okanishi H, Kanai Y, Yano T, Masui R. Nakatani M, et al. Among authors: okanishi h. J Struct Biol. 2022 Dec;214(4):107904. doi: 10.1016/j.jsb.2022.107904. Epub 2022 Oct 11. J Struct Biol. 2022. PMID: 36228973

8

Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of L-type amino acid transporter 1.

Okanishi H, Ohgaki R, Xu M, Endou H, Kanai Y. Okanishi H, et al. Cancer Metab. 2022 Nov 10;10(1):18. doi: 10.1186/s40170-022-00295-8. Cancer Metab. 2022. PMID: 36357940 Free PMC article.

9

Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells.

Nishikubo K, Ohgaki R, Liu X, Okanishi H, Xu M, Endou H, Kanai Y. Nishikubo K, et al. Among authors: okanishi h. Cancer Cell Int. 2023 Jun 15;23(1):116. doi: 10.1186/s12935-023-02957-z. Cancer Cell Int. 2023. PMID: 37322479 Free PMC article.

10

Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models.

Shi Z, Kaneda-Nakashima K, Ohgaki R, Xu M, Okanishi H, Endou H, Nagamori S, Kanai Y. Shi Z, et al. Among authors: okanishi h. Sci Rep. 2023 Aug 25;13(1):13943. doi: 10.1038/s41598-023-41096-3. Sci Rep. 2023. PMID: 37626086 Free PMC article.

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